Lymphopoiesis is the process in which B and T cells, and innate lymphoid cells (ILCs)
develop from hematopoietic progenitors that exhibit early lymphoid priming. The branching …

Modest response rates to immunotherapy observed in advanced lung cancer patients
underscore the need to identify reliable biomarkers and targets, enhancing both treatment …

The human immune system is made up of a huge variety of cell types each with unique
functions. Local networks of resident immune cells are poised to sense and protect against …

The developmental cartography of human lymphopoiesis remains incompletely understood.
Here, we establish a multimodal map demonstrating that lymphoid specification follows …

Over the past decade our research has implemented a multimodal approach to human
lymphopoiesis, combining clonal-scale mapping of lymphoid developmental architecture …

Embryonic and fetal hematopoietic stem and progenitor cells differ in some key properties
from cells that are part of the adult hematopoietic system. These include higher proliferation …

Childhood is critical for hematopoietic development and the onset of hematologic diseases.
To explore hematopoietic changes from infancy through adolescence, we generated a multi …

Hematopoiesis—from the Greek term for “blood making”—is the adaptive process by which
mature and functional blood cells are continuously replaced over the entire lifetime of an …