Innovation in precision fermentation for food ingredients

MA Augustin, CJ Hartley, G Maloney… - Critical reviews in food …, 2024 - Taylor & Francis
A transformation in our food production system is being enabled by the convergence of
advances in genome-based technologies and traditional fermentation. Science at the …

Machine learning in bioprocess development: from promise to practice

LM Helleckes, J Hemmerich, W Wiechert… - Trends in …, 2023 - cell.com
Fostered by novel analytical techniques, digitalization, and automation, modern bioprocess
development provides large amounts of heterogeneous experimental data, containing …

Bioprocessing in the digital age: the role of process models

H Narayanan, MF Luna, M von Stosch… - Biotechnology …, 2020 - Wiley Online Library
In this age of technology, the vision of manufacturing industries built of smart factories is not
a farfetched future. As a prerequisite for Industry 4.0, industrial sectors are moving towards …

Engineering robust production microbes for large-scale cultivation

M Wehrs, D Tanjore, T Eng, J Lievense, TR Pray… - Trends in …, 2019 - cell.com
Systems biology and synthetic biology are increasingly used to examine and modulate
complex biological systems. As such, many issues arising during scaling-up microbial …

Grand research challenges for sustainable industrial biotechnology

AJJ Straathof, SA Wahl, KR Benjamin, R Takors… - Trends in …, 2019 - cell.com
Future manufacturing will focus on new, improved products as well as on new and
enhanced production methods. Recent biotechnological and scientific advances, such as …

Using gas mixtures of CO, CO2 and H2 as microbial substrates: the do's and don'ts of successful technology transfer from laboratory to production scale

R Takors, M Kopf, J Mampel, W Bluemke… - Microbial …, 2018 - Wiley Online Library
The reduction of CO 2 emissions is a global effort which is not only supported by the society
and politicians but also by the industry. Chemical producers worldwide follow the strategic …

Impeller selection for mixing high-solids lignocellulosic biomass in stirred tank bioreactor for ethanol production

AEK Afedzi, K Rattanaporn… - Bioresource Technology …, 2022 - Elsevier
An important process in ethanol bioprocesses is the mixing in a bioreactor, which is a
general phenomenon. To obtain and maintain mixing efficiency in this process, one of the …

Bubble size and liquid-side mass transfer coefficient measurements in aerated stirred tank reactors with non-Newtonian liquids

V Cappello, C Plais, C Vial, F Augier - Chemical engineering science, 2020 - Elsevier
Oxygen transfer is a key element in aerobic fermentations, especially if the culture broth's
rheology is non-Newtonian, as in the case of cultures of filamentous fungi. Viscosity …

[HTML][HTML] Towards a sustainable supply of omega-3 fatty acids: Screening microalgae for scalable production of eicosapentaenoic acid (EPA)

W Gu, JM Kavanagh, DD McClure - Algal Research, 2022 - Elsevier
There is an increasing need for sustainable sources of omega-3 fatty acids; this challenge
can be addressed through large-scale production of eicosapentaenoic acid (EPA) using …

Engineering of a robust Escherichia coli chassis and exploitation for large-scale production processes

M Ziegler, J Zieringer, CL Döring, L Paul, C Schaal… - Metabolic …, 2021 - Elsevier
In large-scale bioprocesses microbes are exposed to heterogeneous substrate availability
reducing the overall process performance. A series of deletion strains was constructed from …