The structure of neuronal circuits that subserve cognitive functions in the brain is shaped
and refined throughout development and into adulthood. Evidence from human and animal …

A number of studies have indicated that antagonists of the N‐methyl‐d‐aspartate subtypes
of glutamate receptors can cause schizophrenia‐like symptoms in healthy individuals and …

Many risk genes interact synergistically to produce schizophrenia and many
neurotransmitter interactions have been implicated. We have developed a circuit-based …

A substantial and diverse body of literature suggests that the pathophysiology of
schizophrenia is related to deficits of bioenergetic function. While antipsychotics are an …

Epigenetic misregulation is consistent with various non-Mendelian features of schizophrenia
and bipolar disorder. To date, however, few studies have investigated the role of DNA …

More than 70% of adolescents report to have smoked a cigarette at least once. At the
adolescent stage the brain has not completed its maturation. The prefrontal cortex (PFC), the …

Synapses are well known as the main structures responsible for transmitting information
through the release and recognition of neurotransmitters by pre-and post-synaptic neurons …

Abstract System xc− represents an intriguing target in attempts to understand the
pathological states of the central nervous system. Also called a cystine-glutamate antiporter …

Prepulse inhibition (PPI) is the attenuation of the startle reflex when the sudden intense
startling stimulus is shortly preceded by a weaker, non-startling sensory stimulus (prepulse) …

The postsynaptic density (PSD) contains a complex set of proteins of known relevance to
neuropsychiatric disorders, and schizophrenia specifically. We enriched for this anatomical …