Postoperative ileus (POI) and postoperative gastrointestinal tract dysfunction (POGD) are
well-known complications affecting patients undergoing intestinal surgery. GI symptoms …

Opioid overdose is the leading cause of death for Americans 25 to 64 years of age, and
opioid use disorder affects> 2 million Americans. The epidemiology of opioid-associated out …

We analyzed the 16S rRNA amplicon composition in fecal samples of selected patients
during their prolonged stay in an intensive care unit (ICU) and observed the emergence of …

Opioids evoke analgesia through activation of opioid receptors (predominantly the μ opioid
receptor) in the central nervous system. Opioid receptors are abundant in multiple regions of …

Piperine is a natural alkaloid that possesses a variety of therapeutic properties, including
anti-inflammatory, antioxidant, antibacterial, and anticarcinogenic activities. The present …

Opioids were one of the earliest classes of medications used for pain across a variety of
conditions, but morbidity and mortality have been increasingly associated with their chronic …

Constipation affects 14% of the adult population globally, mainly women, and significantly
impacts on health‐related quality of life. The causes of constipation are mainly three: lifestyle …

The gastrointestinal tract (GIT) is the largest interface between our body and the
environment. It is an organ system extending from the mouth to the anus and functions for …

A concise review covering updated presence and role of 2-phenethylamines in medicinal
chemistry is presented. Open-chain, flexible alicyclic amine derivatives of this motif are …

Background Cannabinoid hyperemesis syndrome (CHS) is a challenging clinical disorder.
CHS patients frequently present to the emergency department and may require treatment for …