DNA replication is central to cell proliferation. Studies in the past six decades since the
proposal of a semiconservative mode of DNA replication have confirmed the high degree of …

Cellular DNA replication is initiated through the action of multiprotein complexes that
recognize replication start sites in the chromosome (termed origins) and facilitate duplex …

Proper eukaryotic DNA replication requires temporal separation of helicase loading from
helicase activation and replisome assembly. Using an in vitro assay for eukaryotic origin …

Chromosome replication occurs precisely once during the cell cycle of almost all eukaryotic
cells, and is a highly complex process that is still understood relatively poorly. Two …

Eukaryotic DNA replication is regulated to ensure all chromosomes replicate once and only
once per cell cycle. Replication begins at many origins scattered along each chromosome …

DNA replication is tightly controlled in eukaryotic cells to ensure that an exact copy of the
genetic material is inherited by both daughter cells. Oscillating waves of cyclin-dependent …

Background Chromosomal DNA replication in eukaryotes initiates from multiple origins of
replication, and because of this multiplicity, activation of replication origins is likely to be …

One of the long-standing questions in eukaryotic DNA replication is the mechanisms that
determine where and when a particular segment of the genome is replicated. Cdc7/Hsk1 is …

Highlights•The eukaryotic MCM replicative helicase is tightly regulated during the cell
cycle.•Conformational changes in MCM underpin the different stages of chromosome …

Eukaryotic chromosomal DNA replication requires cyclin-dependent kinase (CDK) activity.
CDK phosphorylates two yeast replication proteins, Sld3 and Sld2, both of which bind to …