Comprehensive Study of the Clinical Phenotype of Germline BAP1 Variant-Carrying Families Worldwide
S Walpole, AL Pritchard, CM Cebulla… - JNCI: Journal of the …, 2018 - academic.oup.com
Background The BRCA1-associated protein-1 (BAP1) tumor predisposition syndrome (BAP1-
TPDS) is a hereditary tumor syndrome caused by germline pathogenic variants in BAP1 …
TPDS) is a hereditary tumor syndrome caused by germline pathogenic variants in BAP1 …
miRTarBase 2020: updates to the experimentally validated microRNA–target interaction database
MicroRNAs (miRNAs) are small non-coding RNAs (typically consisting of 18–25
nucleotides) that negatively control expression of target genes at the post-transcriptional …
nucleotides) that negatively control expression of target genes at the post-transcriptional …
miRTarBase update 2018: a resource for experimentally validated microRNA-target interactions
MicroRNAs (miRNAs) are small non-coding RNAs of∼ 22 nucleotides that are involved in
negative regulation of mRNA at the post-transcriptional level. Previously, we developed …
negative regulation of mRNA at the post-transcriptional level. Previously, we developed …
New functionalities in the TCGAbiolinks package for the study and integration of cancer data from GDC and GTEx
The advent of Next-Generation Sequencing (NGS) technologies has opened new
perspectives in deciphering the genetic mechanisms underlying complex diseases …
perspectives in deciphering the genetic mechanisms underlying complex diseases …
Drug design and disease diagnosis: the potential of deep learning models in biology
S Sreeraman, MP Kannan… - Current …, 2023 - ingentaconnect.com
Early prediction and detection enable reduced transmission of human diseases and provide
healthcare professionals ample time to make subsequent diagnoses and treatment …
healthcare professionals ample time to make subsequent diagnoses and treatment …
A circRNA–miRNA–mRNA network identification for exploring underlying pathogenesis and therapy strategy of hepatocellular carcinoma
D Xiong, Y Dang, P Lin, D Wen, R He, D Luo… - Journal of translational …, 2018 - Springer
Abstract Background Circular RNAs (circRNAs) have received increasing attention in human
tumor research. However, there are still a large number of unknown circRNAs that need to …
tumor research. However, there are still a large number of unknown circRNAs that need to …
miRTarBase update 2022: an informative resource for experimentally validated miRNA–target interactions
MicroRNAs (miRNAs) are noncoding RNAs with 18–26 nucleotides; they pair with target
mRNAs to regulate gene expression and produce significant changes in various …
mRNAs to regulate gene expression and produce significant changes in various …
Computational techniques and tools for omics data analysis: state-of-the-art, challenges, and future directions
The heterogeneous and high-dimensional nature of omics data presents various challenges
in gaining insights while analysis. In the era of big data, omics data is available as genome …
in gaining insights while analysis. In the era of big data, omics data is available as genome …
Significance of tumor mutation burden combined with immune infiltrates in the progression and prognosis of ovarian cancer
F Bi, Y Chen, Q Yang - Cancer cell international, 2020 - Springer
Background Ovarian cancer (OC) is the most malignant tumor in the female reproductive
system. About 75% of OC in complete remission of clinical symptoms still develop a …
system. About 75% of OC in complete remission of clinical symptoms still develop a …
Characterization of glycolysis-associated molecules in the tumor microenvironment revealed by pan-cancer tissues and lung cancer single cell data
J Wei, K Huang, Z Chen, M Hu, Y Bai, S Lin, H Du - Cancers, 2020 - mdpi.com
Altered metabolism is a hallmark of cancer and glycolysis is one of the important factors
promoting tumor development. There is however still a lack of molecular characterization …
promoting tumor development. There is however still a lack of molecular characterization …