Mito-morphosis: mitochondrial fusion, fission, and cristae remodeling as key mediators of cellular function

L Pernas, L Scorrano - Annual review of physiology, 2016 - annualreviews.org
Permanent residency in the eukaryotic cell pressured the prokaryotic mitochondrial ancestor
to strategize for intracellular living. Mitochondria are able to autonomously integrate and …

Mitochondrial fusion and fission in cell life and death

B Westermann - Nature reviews Molecular cell biology, 2010 - nature.com
Mitochondria are dynamic organelles that constantly fuse and divide. These processes
(collectively termed mitochondrial dynamics) are important for mitochondrial inheritance and …

Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells

E Smirnova, L Griparic, DL Shurland… - Molecular biology of …, 2001 - Am Soc Cell Biol
Mutations in the human dynamin-related protein Drp1 cause mitochondria to form
perinuclear clusters. We show here that these mitochondrial clusters consist of highly …

Mitochondrial fusion and fission in mammals

DC Chan - Annu. Rev. Cell Dev. Biol., 2006 - annualreviews.org
Eukaryotic cells maintain the overall shape of their mitochondria by balancing the opposing
processes of mitochondrial fusion and fission. Unbalanced fission leads to mitochondrial …

The inheritance of genes in mitochondria and chloroplasts: laws, mechanisms, and models

CW Birky Jr - Annual review of genetics, 2001 - annualreviews.org
▪ Abstract The inheritance of mitochondrial and chloroplast genes differs from that of nuclear
genes in showing vegetative segregation, uniparental inheritance, intracellular selection …

Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p

AD Mozdy, JM McCaffery, JM Shaw - The Journal of cell biology, 2000 - rupress.org
Yeast Dnm1p is a soluble, dynamin-related GTPase that assembles on the outer
mitochondrial membrane at sites where organelle division occurs. Although these Dnm1p …

FtsZ and the division of prokaryotic cells and organelles

W Margolin - Nature reviews Molecular cell biology, 2005 - nature.com
Binary fission of many prokaryotes as well as some eukaryotic organelles depends on the
FtsZ protein, which self-assembles into a membrane-associated ring structure early in the …

Mitochondrial fission and fusion

I Scott, RJ Youle - Essays in biochemistry, 2010 - portlandpress.com
Mitochondria are highly dynamic cellular organelles, with the ability to change size, shape
and position over the course of a few seconds. Many of these changes are related to the …

The dynamin-related GTPase, Mgm1p, is an intermembrane space protein required for maintenance of fusion competent mitochondria

ED Wong, JA Wagner, SW Gorsich… - The Journal of cell …, 2000 - rupress.org
Mutations in the dynamin-related GTPase, Mgm1p, have been shown to cause
mitochondrial aggregation and mitochondrial DNA loss in Saccharomyces cerevisiae cells …

A century of mitochondrial research: achievements and perspectives

IE Scheffler - Mitochondrion, 2001 - Elsevier
A recent issue of Science (Vol. 283, March 5, 1999) had a cover showing a mitochondrion
and a headline inside asserting thatMitochondria Make A Comeback'. Why the revival of …