Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

Aquaculture is the productive activity that will play a crucial role in the challenges of the
millennium, such as the need for proteins that support humans and the respect for the …

Prolonged high-temperature extreme events in the ocean, marine heatwaves, can have
severe and long-lasting impacts on marine ecosystems, fisheries and associated services …

The protein folding problem was first articulated as question of how order arose from
disorder in proteins: How did the various native structures of proteins arise from interatomic …

The most common mechanism of resistance to β-lactam antibiotics in Gram-negative
bacteria is the production of β-lactamases that hydrolyze the drugs. Class A β-lactamases …

Advances in sequencing techniques and statistical methods have made it possible not only
to predict sequences of ancestral proteins but also to identify thousands of mutations in the …

Background Antibiotic resistance leads to longer hospital stays, higher medical costs, and
increased mortality. However, research into the relationship between climate change and …

Natural products serve as chemical blueprints for most antibiotics in clinical use. The
evolutionary process by which these molecules arise is inherently accompanied by the co …

Epistasis, the non-additive effect of mutations, can provide combinatorial improvements to
enzyme activity that substantially exceed the gains from individual mutations. Yet the …

Bacteria have evolved diverse mechanisms to survive environments with antibiotics.
Temperature is both a key factor that affects the survival of bacteria in the presence of …