In the early 1950s, Austin and Chang independently described the changes that are
required for the sperm to fertilize oocytes in vivo. These changes were originally grouped …

Mammalian sperm cells must respond to cues originating from along the female
reproductive tract and from the layers of the egg in order to complete their fertilization …

Steroid hormone progesterone released by cumulus cells surrounding the egg is a potent
stimulator of human spermatozoa. It attracts spermatozoa towards the egg and helps them …

A proper dialogue between spermatozoa and the egg is essential for conception of a new
individual in sexually reproducing animals. Ca2+ is crucial in orchestrating this unique event …

BACKGROUND Sperm hyperactivation is critical to fertilization, because it is required for
penetration of the zona pellucida. Hyperactivation may also facilitate release of sperm from …

Mammalian spermatozoa become motile at ejaculation, but before they can fertilize the egg,
they must acquire more thrust to penetrate the cumulus and zona pellucida. The forceful …

Ion channels control the sperm ability to fertilize the egg by regulating sperm maturation in
the female reproductive tract and by triggering key sperm physiological responses required …

In mammals, sperm cells become motile during ejaculation and swim up the female
reproductive tract. Before fertilization and to overcome various barriers, their motility must be …

Spermatozoa must leave one organism, navigate long distances, and deliver their paternal
DNA into a mature egg. For successful navigation and delivery, a sperm-specific calcium …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …