The pineal gland-derived indoleamine hormone, melatonin, regulates multiple cellular
processes, ranging from chronobiology, proliferation, apoptosis, and oxidative damage to …

Background Acute myeloid leukaemia (AML) is a deadly disease characterised by the
uncontrolled proliferation of immature myeloid cells within the bone marrow. Altered …

Single-cell DNA methylation sequencing is highly effective for identifying cell
subpopulations and constructing epigenetic regulatory networks. Existing methylome …

Assessment of measurable residual disease (MRD) upon treatment of acute myeloid
leukemia (AML) remains challenging. It is usually addressed by highly sensitive PCR-or …

The aim of our review has been to give an appropriate idea of analogies and differences
between primitive MDS (p-MDS) and t-MDS throughout an accurate reviewing of English …

Th cell lineage determination and functional specialization are tightly linked to the activation
of lineage-determining transcription factors (TFs) that bind cis-regulatory elements. These …

PURPOSE AML is a hematologic cancer that is clinically heterogeneous, with a wide range
of clinical outcomes. DNA methylation changes are a hallmark of AML but are not routinely …

Familial platelet disorder with associated myeloid malignancies (FPDMM) is an autosomal
dominant disease caused by heterozygous germline mutations in RUNX1. It is characterized …

The azanucleosides decitabine and azacytidine are used widely in the treatment of myeloid
neoplasia and increasingly in the context of combination therapies. Although they were long …

Simple Summary The genome is stored in the limited space of the nucleus in a highly
condensed form. The regulation of this packaging contributes to determining the …