[HTML][HTML] Oncometabolite lactate enhances breast cancer progression by orchestrating histone lactylation-dependent c-Myc expression
Due to the enhanced glycolytic rate, cancer cells generate lactate copiously, subsequently
promoting the lactylation of histones. While previous studies have explored the impact of …
promoting the lactylation of histones. While previous studies have explored the impact of …
Discovery of a potent and selective CBP bromodomain inhibitor (Y08262) for treating acute myeloid leukemia
Q Xiang, T Wu, C Zhang, C Wang, H Xu, Q Hu, J Hu… - Bioorganic …, 2024 - Elsevier
The bromodomain of CREB (cyclic-AMP response element binding protein) binding protein
(CBP) is an epigenetic “reader” and plays a key role in transcriptional regulation. CBP …
(CBP) is an epigenetic “reader” and plays a key role in transcriptional regulation. CBP …
Proposals for Clinical Trials in Chronic Myelomonocytic Leukemia
A Rezazadeh, M Deininger, E Atallah - Current Treatment Options in …, 2023 - Springer
Opinion statement Chronic myelomonocytic leukemia (CMML) is a clonal hematologic
malignancy of mostly older individuals that exhibits both myelodysplastic and …
malignancy of mostly older individuals that exhibits both myelodysplastic and …
Epigenetics and alternative splicing in cancer: old enemies, new perspectives.
MR Pandkar, S Shukla - Biochemical Journal, 2024 - search.ebscohost.com
In recent years, significant strides in both conceptual understanding and technological
capabilities have bolstered our comprehension of the factors underpinning cancer initiation …
capabilities have bolstered our comprehension of the factors underpinning cancer initiation …