Advancing cell-based cancer immunotherapy through stem cell engineering
Advances in cell-based therapy, particularly CAR-T cell therapy, have transformed the
treatment of hematological malignancies. Although an important step forward for the field …
treatment of hematological malignancies. Although an important step forward for the field …
Exploring the dynamic interplay between cancer stem cells and the tumor microenvironment: implications for novel therapeutic strategies
Cancer stem cells (CSCs) have emerged as key contributors to tumor initiation, growth, and
metastasis. In addition, CSCs play a significant role in inducing immune evasion, thereby …
metastasis. In addition, CSCs play a significant role in inducing immune evasion, thereby …
Mucosal-associated invariant T cells for cancer immunotherapy
YR Li, K Zhou, M Wilson, A Kramer, Y Zhu, N Dawson… - Molecular Therapy, 2023 - cell.com
Human mucosal-associated invariant T (MAIT) cells are characterized by their expression of
an invariant TCR α chain Vα7. 2-Jα33/Jα20/Jα12 paired with a restricted TCR β chain. MAIT …
an invariant TCR α chain Vα7. 2-Jα33/Jα20/Jα12 paired with a restricted TCR β chain. MAIT …
Targeting immunosuppressive tumor-associated macrophages using innate T cells for enhanced antitumor reactivity
Simple Summary This study seeks to evaluate innate T cells for antitumor therapies that can
target both tumor cells and immunosuppressive tumor-associated macrophages (TAMs) …
target both tumor cells and immunosuppressive tumor-associated macrophages (TAMs) …
Target tumor microenvironment by innate T cells
The immunosuppressive tumor microenvironment (TME) remains one of the most prevailing
barriers obstructing the implementation of effective immunotherapy against solid-state …
barriers obstructing the implementation of effective immunotherapy against solid-state …
Off-the-shelf third-party HSC-engineered iNKT cells for ameliorating GvHD while preserving GvL effect in the treatment of blood cancers
Allo-HSCT is a curative therapy for hematologic malignancies owing to GvL effect mediated
by alloreactive T cells; however, the same T cells also mediate GvHD, a severe side effect …
by alloreactive T cells; however, the same T cells also mediate GvHD, a severe side effect …
Tumor-localized administration of α-GalCer to recruit invariant natural killer T cells and enhance their antitumor activity against solid tumors
Invariant natural killer T (iNKT) cells have the capacity to mount potent anti-tumor reactivity
and have therefore become a focus in the development of cell-based immunotherapy. iNKT …
and have therefore become a focus in the development of cell-based immunotherapy. iNKT …
Profiling ovarian cancer tumor and microenvironment during disease progression for cell-based immunotherapy design
YR Li, CJ Ochoa, Y Zhu, A Kramer, M Wilson, Y Fang… - Iscience, 2023 - cell.com
Ovarian cancer (OC) is highly lethal due to late detection and frequent recurrence. Initial
treatments, comprising surgery and chemotherapy, lead to disease remission but are …
treatments, comprising surgery and chemotherapy, lead to disease remission but are …
Invariant natural killer T cells in lung diseases
D Jeong, YD Woo, DH Chung - Experimental & Molecular Medicine, 2023 - nature.com
Invariant natural killer T (i NKT) cells are a subset of T cells that are characterized by a
restricted T-cell receptor (TCR) repertoire and a unique ability to recognize glycolipid …
restricted T-cell receptor (TCR) repertoire and a unique ability to recognize glycolipid …
[HTML][HTML] Advancements in CRISPR screens for the development of cancer immunotherapy strategies
CRISPR screen technology enables systematic and scalable interrogation of gene function
by using the CRISPR-Cas9 system to perturb gene expression. In the field of cancer …
by using the CRISPR-Cas9 system to perturb gene expression. In the field of cancer …