During metastasis, cancer cells disseminate to other parts of the body by entering the
bloodstream in a process that is called intravasation. They then extravasate at metastatic …

Cancer invasion is a cell-and tissue-driven process for which the physical, cellular, and
molecular determinants adapt and react throughout the progression of the disease. Cancer …

Simple Summary Cell migration is an essential process from embryogenesis to cell death.
This is tightly regulated by numerous proteins that help in proper functioning of the cell. In …

The cortex is a thin, crosslinked actin network lying immediately beneath the plasma
membrane of animal cells. Myosin motors exert contractile forces in the meshwork. Because …

The molecular requirements and morphology of migrating cells can vary depending on
matrix geometry; therefore, predicting the optimal migration strategy or the effect of …

Members of the ezrin–radixin–moesin (ERM) family of proteins are involved in multiple
aspects of cell migration by acting both as crosslinkers between the membrane, receptors …

Remodeling of actin filaments is necessary for epithelial–mesenchymal transition (EMT);
however, understanding of how this is regulated in real time is limited. We used an actin …

Loss of epithelial organization is a hallmark of carcinomas, but whether polarity regulates
tumor growth and metastasis is poorly understood. To address this issue, we depleted the …

Abstract The small Rho GTPase family of proteins, encompassing the three major G-protein
classes Rho, Rac and cell division control protein 42, are key mitogenic signaling molecules …

Systemically administered adult mesenchymal stem cells (MSCs), which are being explored
in clinical trials to treat inflammatory disease, exhibit the critical ability to extravasate at sites …