Impaired protein homeostasis and accumulation of damaged or abnormally modified protein
are common disease mechanisms in many neurodegenerative disorders, including …

Understanding the function of genes mutated in hereditary forms of Parkinson's disease
yields insight into disease etiology and reveals new pathways in cell biology. Although …

Mitophagy is a cellular quality control pathway in which the E3 ubiquitin ligase parkin targets
damaged mitochondria for degradation by autophagosomes. We examined the role of …

Damaged mitochondria are removed by mitophagy. Although Atg32 is essential for
mitophagy in yeast, no Atg32 homologue has been identified in mammalian cells. Here, we …

Damage to mitochondria can lead to the depolarization of the inner mitochondrial
membrane, thereby sensitizing impaired mitochondria for selective elimination by …

Mitochondria play an essential role in maintaining cellular homeostasis. The removal of
damaged or depolarized mitochondria occurs via mitophagy, in which damaged …

Loss-of-function mutations in Park2, the gene coding for the ubiquitin ligase Parkin, are a
significant cause of early onset Parkinson's disease. Although the role of Parkin in neuron …

Neurons are critically dependent on mitochondrial integrity based on specific morphological,
biochemical, and physiological features. They are characterized by high rates of metabolic …

Parkinson's disease (PD) is a common motor disorder of mysterious etiology. It is due to the
progressive degeneration of the dopaminergic neurons of the substantia nigra and is …

Parkinson's disease (PD) is a prevalent neurodegenerative disorder. Recent identification of
genes linked to familial forms of PD such as Parkin and PINK1 (PTEN-induced putative …