Cerebral cavernous malformation: from mechanism to therapy

DA Snellings, CC Hong, AA Ren… - Circulation …, 2021 - Am Heart Assoc
Cerebral cavernous malformations are acquired vascular anomalies that constitute a
common cause of central nervous system hemorrhage and stroke. The past 2 decades have …

Cavernous angiomas: deconstructing a neurosurgical disease: JNSPG 75th Anniversary Invited Review Article

IA Awad, SP Polster - Journal of neurosurgery, 2019 - thejns.org
Cavernous angioma (CA) is also known as cavernoma, cavernous hemangioma, and
cerebral cavernous malformation (CCM)(National Library of Medicine Medical Subject …

Familial cerebral cavernous malformations

A Zafar, SA Quadri, M Farooqui, A Ikram, M Robinson… - Stroke, 2019 - Am Heart Assoc
surface interactions between these as well as with numerous binding partners. 17 FCCM is
inherited in an autosomal dominant fashion, with every affected parent having a 50 …

Cerebral cavernous malformation: what a practicing clinician should know

KD Flemming, G Lanzino - Mayo Clinic Proceedings, 2020 - Elsevier
Cavernous malformations (CMs) are angiographically occult, low-flow vascular
malformations of the central nervous system. They are acquired lesions, with approximately …

Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation

MA Lopez-Ramirez, CC Lai, SI Soliman… - The Journal of …, 2021 - Am Soc Clin Investig
Cerebral cavernous malformations (CCMs) are common neurovascular lesions caused by
loss-of-function mutations in 1 of 3 genes, including KRIT1 (CCM1), CCM2, and PDCD10 …

Neuroinflammation plays a critical role in cerebral cavernous malformation disease

CC Lai, B Nelsen, E Frias-Anaya… - Circulation …, 2022 - Am Heart Assoc
Background: Cerebral cavernous malformations (CCMs) are neurovascular lesions caused
by loss of function mutations in 1 of 3 genes, including KRIT1 (CCM1), CCM2, and PDCD10 …

Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice

MA Lopez-Ramirez, A Pham, R Girard… - Blood, The Journal …, 2019 - ashpublications.org
Cerebral cavernous malformations (CCMs) are common brain vascular dysplasias that are
prone to acute and chronic hemorrhage with significant clinical sequelae. The pathogenesis …

Cerebral cavernous malformations: Typical and atypical imaging characteristics

D Kuroedov, B Cunha, J Pamplona… - Journal of …, 2023 - Wiley Online Library
Cavernous malformations (CMs) are benign vascular malformations that maybe seen
anywhere in the central nervous system. They are dynamic lesions, growing or shrinking …

mPR-specific actions influence maintenance of the blood–brain barrier (BBB)

J Abou-Fadel, X Jiang, A Padarti, DG Goswami… - International Journal of …, 2022 - mdpi.com
Cerebral cavernous malformations (CCMs) are characterized by abnormally dilated
intracranial microvascular sinusoids that result in increased susceptibility to hemorrhagic …

[HTML][HTML] Common lipidomic signatures across distinct acute brain injuries in patient outcome prediction

S Hellström, A Sajanti, A Srinath, C Bennett… - Neurobiology of …, 2025 - Elsevier
Lipidomic alterations have been associated with various neurological diseases. Examining
temporal changes in serum lipidomic profiles, irrespective of injury type, reveals promising …