The ArcAB two-component system: function in metabolism, redox control, and infection

AN Brown, MT Anderson, MA Bachman… - Microbiology and …, 2022 - Am Soc Microbiol
ArcAB, also known as the Arc system, is a member of the two-component system family of
bacterial transcriptional regulators and is composed of sensor kinase ArcB and response …

Signaling by the arc two-component system provides a link between the redox state of the quinone pool and gene expression

R Malpica, GRP Sandoval, C Rodríguez… - Antioxidants & redox …, 2006 - liebertpub.com
The Arc two-component system is a complex signal transduction system that plays a key role
in regulating energy metabolism at the level of transcription in bacteria. This system …

Quinones as the redox signal for the arc two-component system of bacteria

D Georgellis, O Kwon, ECC Lin - Science, 2001 - science.org
The Arc two-component signal transduction system mediates adaptive responses of
Escherichia coli to changing respiratory conditions of growth. Under anaerobic conditions …

Overflow Metabolism in Escherichia coli during Steady-State Growth: Transcriptional Regulation and Effect of the Redox Ratio

GN Vemuri, E Altman, DP Sangurdekar… - Applied and …, 2006 - Am Soc Microbiol
Overflow metabolism in the form of aerobic acetate excretion by Escherichia coli is an
important physiological characteristic of this common industrial microorganism. Although …

Integrating anaerobic/aerobic sensing and the general stress response through the ArcZ small RNA

P Mandin, S Gottesman - The EMBO journal, 2010 - embopress.org
The alternative sigma factor RpoS responds to multiple stresses and activates a large
number of genes that allow bacteria to adapt to changing environments. The accumulation …

A two-component phosphotransfer network involving ArcB, ArcA, and RssB coordinates synthesis and proteolysis of σS (RpoS) in E. coli

F Mika, R Hengge - Genes & development, 2005 - genesdev.cshlp.org
The general stress σ factor σS (RpoS) in Escherichia coli is controlled at the levels of
transcription, translation, and proteolysis. Here we demonstrate that the phosphorylated …

Probing the ArcA-P modulon of Escherichia coli by whole genome transcriptional analysis and sequence recognition profiling

X Liu, P De Wulf - Journal of Biological Chemistry, 2004 - ASBMB
The ArcB/ArcA two-component signal transduction system of Escherichia coli regulates gene
expression in response to the redox conditions of growth. Over the years, genetic screens …

A Gibbs sampler for identification of symmetrically structured, spaced DNA motifs with improved estimation of the signal length

AV Favorov, MS Gelfand, AV Gerasimova… - …, 2005 - academic.oup.com
Motivation: Transcription regulatory protein factors often bind DNA as homo-dimers or hetero-
dimers. Thus they recognize structured DNA motifs that are inverted or direct repeats or …

Determining the control circuitry of redox metabolism at the genome-scale

S Federowicz, D Kim, A Ebrahim, J Lerman… - PLoS …, 2014 - journals.plos.org
Determining how facultative anaerobic organisms sense and direct cellular responses to
electron acceptor availability has been a subject of intense study. However, even in the …

Amplification of signaling activity of the Arc two-component system of Escherichia coli by anaerobic metabolites: an in vitro study with different protein modules

D Georgellis, O Kwon, ECC Lin - Journal of Biological Chemistry, 1999 - ASBMB
In Escherichia coli, changes in redox condition of growth are sensed and signaled by the Arc
two-component system. This system consists of ArcB as the membrane-associated sensor …