Integrinβ-1 in disorders and cancers: molecular mechanisms and therapeutic targets

C Su, J Mo, S Dong, Z Liao, B Zhang, P Zhu - Cell Communication and …, 2024 - Springer
Abstract Integrinβ-1 (ITGB1) is a crucial member of the transmembrane glycoprotein
signaling receptor family and is also central to the integrin family. It forms heterodimers with …

ALDEFLUOR activity, ALDH isoforms, and their clinical significance in cancers

JJ Duan, J Cai, L Gao, SC Yu - Journal of Enzyme Inhibition and …, 2023 - Taylor & Francis
High aldehyde dehydrogenase (ALDH) activity is a metabolic feature of adult stem cells and
various cancer stem cells (CSCs). The ALDEFLUOR system is currently the most commonly …

N6-methyladenosine-modified ALDH9A1 modulates lipid accumulation and tumor progression in clear cell renal cell carcinoma through the NPM1/IQGAP2/AKT …

D Tan, D Miao, C Zhao, J Shi, Q Lv, F Lu, H Ruan… - Cell Death & …, 2024 - nature.com
Aldehyde dehydrogenases superfamily (ALDHs), which are ubiquitously present in various
organisms with diverse subcellular localizations, play a crucial role in regulating malignant …

Aldehyde dehydrogenase in solid tumors and other diseases: Potential biomarkers and therapeutic targets

J Xia, S Li, S Liu, L Zhang - MedComm, 2023 - Wiley Online Library
The family of aldehyde dehydrogenases (ALDHs) contains 19 isozymes and is involved in
the oxidation of endogenous and exogenous aldehydes to carboxylic acids, which …

Single-cell transcriptomics of the immune system in ME/CFS at baseline and following symptom provocation

LT Vu, F Ahmed, H Zhu, DSH Iu, EA Fogarty… - Cell Reports …, 2024 - cell.com
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious and poorly
understood disease. To understand immune dysregulation in ME/CFS, we use single-cell …

Mdact: A new principle of adjunctive cancer treatment using combinations of multiple repurposed drugs, with an example regimen

RE Kast, A Alfieri, HI Assi, TC Burns, AM Elyamany… - Cancers, 2022 - mdpi.com
Simple Summary We present eight core attributes of cancer growth that we must address for
a more effective treatment than we currently have. To do this we outline why a regimen …

Research progress of bile biomarkers and their immunoregulatory role in biliary tract cancers

Y Li, K Li, Z Liu, Y Tang, XQ Hu, X Li, A Shi… - Frontiers in …, 2022 - frontiersin.org
Biliary tract cancers (BTCs), including cholangiocarcinoma and gallbladder carcinoma,
originate from the biliary epithelium and have a poor prognosis. Surgery is the only choice …

CD248 promotes migration and metastasis of osteosarcoma through ITGB1-mediated FAK-paxillin pathway activation

S Lu, T Lu, J Zhang, L Gan, X Wu, D Han, K Zhang… - BMC cancer, 2023 - Springer
Background Osteosarcoma (OS) is the most common malignant bone tumor with a high
incidence in children and adolescents. Frequent tumor metastasis and high postoperative …

BBOX1 mediates metabolic reprogramming driven by hypoxia and participates in the malignant progress of high-grade serous ovarian cancer

J Huang, Y Tang, Y Li, W Wei, F Kang, S Tan… - … et Biophysica Acta (BBA …, 2024 - Elsevier
High-grade serous ovarian cancer (HGSOC) is the most aggressive type of ovarian cancer
that causes great threats to women's health. Therefore, we performed RNA-sequencing …

Integrated transcriptome profiling identifies prognostic hub genes as therapeutic targets of glioblastoma: evidenced by bioinformatics analysis

C Nayak, SK Singh - ACS omega, 2022 - ACS Publications
Glioblastoma (GBM) is the most devastating and frequent type of primary brain tumor with
high morbidity and mortality. Despite the use of surgical resection followed by radio-and …