Parkinson's disease (PD) is characterized by the loss of neuronal cells, which leads to
synaptic dysfunction and cognitive defects. Despite the advancements in treatment …

The interaction between peripheral immune cells and the brain is an important component of
the neuroimmune axis. Unconventional T cells, which include natural killer T (NKT) cells …

Lipids represent the most abundant molecular type in the brain, with a fat content of∼ 60%
of the dry brain weight in humans. Despite this fact, little attention has been paid to …

The brain contains the highest concentration of cholesterol in the human body, which
emphasizes the importance of cholesterol in brain physiology. Cholesterol is involved in …

Increased life expectancy, attributed to improved access to healthcare and drug
development, has led to an increase in multimorbidity, a key contributor to polypharmacy …

Stroke is a major cause of death and disability worldwide, with the majority of cases resulting
from ischemic events due to arterial occlusion. Current therapeutic approaches focus on …

Abstract “Lipid raft aging” in nerve cells represents an early event in the development of
aging‐related neurodegenerative diseases, such as Alzheimer's disease. Lipid rafts are key …

Gangliosides in the brain play a crucial role in modulating the integrity of vertebrate central
nervous system in a region-specific manner. However, to date, a comprehensive structural …

Biopsy, including tissue and liquid biopsy, offers comprehensive and real-time physiological
and pathological information for disease detection, diagnosis, and monitoring. Fluorescent …

Abstract Changes in lipid metabolism are associated with aging and age-related diseases,
including proteopathies. The endoplasmic reticulum (ER) is uniquely a major hub for protein …