Selective androgen receptor modulators: current knowledge and clinical applications

ZJ Solomon, JR Mirabal, DJ Mazur… - Sexual medicine …, 2019 - academic.oup.com
Introduction Selective androgen receptor modulators (SARMs) differentially bind to
androgen receptors depending on each SARM's chemical structure. As a result, SARMs …

Inflammatory mediators in the development and progression of benign prostatic hyperplasia

C De Nunzio, F Presicce, A Tubaro - Nature reviews urology, 2016 - nature.com
Benign prostatic hyperplasia (BPH) is the most common urological disease in elderly men.
Epidemiological data suggest a causal link between this condition and prostatic …

Low testosterone levels predict clinical adverse outcomes in SARS‐CoV‐2 pneumonia patients

G Rastrelli, V Di Stasi, F Inglese, M Beccaria… - …, 2021 - Wiley Online Library
Background The pandemic of new severe acute respiratory syndrome (SARS) due to
coronavirus (CoV) 2 (SARS‐CoV‐2) has stressed the importance of effective diagnostic and …

[HTML][HTML] Testosterone: a vascular hormone in health and disease

DM Kelly, TH Jones - Journal of Endocrinology, 2013 - joe.bioscientifica.com
Coronary heart disease is a leading cause of premature death in men. Epidemiological
studies have shown a high prevalence of low serum testosterone levels in men with …

Do androgens modulate the pathophysiological pathways of inflammation? Appraising the contemporary evidence

A Traish, J Bolanos, S Nair, F Saad… - Journal of clinical …, 2018 - mdpi.com
The role of testosterone in the pathophysiology of inflammation is of critical clinical
importance; however, no universal mechanism (s) has been advanced to explain the …

Endocrinology of the aging prostate: current concepts

R Cannarella, RA Condorelli, F Barbagallo… - Frontiers in …, 2021 - frontiersin.org
Benign prostate hyperplasia (BPH), one of the most common diseases in older men,
adversely affects quality-of-life due to the presence of low urinary tract symptoms (LUTS) …

Benign prostatic hyperplasia: a new metabolic disease?

L Vignozzi, G Rastrelli, G Corona, M Gacci… - Journal of …, 2014 - Springer
Background Benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS)
are conditions extremely prevalent in the aging male. Although androgens are involved in …

Lower urinary tract symptoms, benign prostatic hyperplasia and metabolic syndrome

L Vignozzi, M Gacci, M Maggi - Nature Reviews Urology, 2016 - nature.com
Epidemiological studies have shown that age is the principal unmodifiable risk factor of
lower urinary tract symptoms (LUTS). Until the past decade, the process of lower urinary tract …

Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator

ML Zhu, P Bakhru, B Conley, JS Nelson, M Free… - Nature …, 2016 - nature.com
Male gender is protective against multiple sclerosis and other T-cell-mediated autoimmune
diseases. This protection may be due, in part, to higher androgen levels in males. Androgen …

Current knowledge of the potential links between inflammation and prostate cancer

T Cai, R Santi, I Tamanini, IC Galli, G Perletti… - International journal of …, 2019 - mdpi.com
Inflammation is inherent in prostatic diseases and it is now accepted that it may facilitate
cellular proliferation in both benign and malignant conditions. The strong relationship …