Recent studies have identified a specialized subset of CD31hiendomucinhi
(CD31hiEMCNhi) vascular endothelium that positively regulates bone formation. However, it …

Static magnetic fields (SMFs), magnetic fields with constant intensity and orientation, have
been extensively studied in the field of bone biology both fundamentally and clinically as a …

RNAi-based bone anabolic gene therapy has demonstrated initial success, but many
practical challenges are still unmet. Here, we demonstrate that a recombinant adeno …

Treating osteoporosis and associated bone fractures remains challenging for drug
development in part due to potential off-target side effects and the requirement for long-term …

Iron oxide nanoparticles (IONPs) are extensively used in bone-related studies as
biomaterials due to their unique magnetic properties and good biocompatibility. Through …

Improper activity of bone-resorbing osteoclasts results in low bone density and deterioration
of bone structure, which increase the risk of fractures. Anti-resorptive therapies targeting …

Osteogenesis imperfecta (OI) is a disorder of low bone mass and increased fracture risk due
to a range of genetic variants that prominently include mutations in genes encoding type I …

Mesenchymal stem cells (MSCs) have potential ability to differentiate into osteocytes in
response to in vitro specific induction. However, the molecular basis underlying this …

Background Diabetic osteoporosis (DOP) is a systemic metabolic bone disease caused by
diabetes mellitus (DM). Adipose-derived stem cells (ASCs) play an important role in bone …

The axon guidance cue SLIT3 was identified as an osteoanabolic agent in two recent
reports. However, these reports conflict in their nomination of osteoblasts versus osteoclasts …