Macrocyclic hosts, such as cyclodextrins, calixarenes, cucurbiturils, and pillararenes, exhibit
unparalleled advantages in disease diagnosis and therapy over the past years by fully …

The blood–brain barrier (BBB) is formed by brain microvascular endothelial cells that are
sealed by tight junctions, making it a significant obstacle for most brain therapeutics. The …

All intravenous delivered nanomedicine needs to escape from the blood vessel to exert their
therapeutic efficacy at their designated site of action. Failure to do so increases the …

Nose-to-brain drug delivery has recently attracted enormous attention as an alternative to
other delivery routes, including the most popular oral one. Due to the unique anatomical …

The study is aimed at elucidating the effect of selenium nanoparticles (SeNPs) on the death
of cells in the primary culture of mouse cerebral cortex during oxygen and glucose …

Exosomes are small extracellular vehicles which could transport genetic materials and
proteins between cells. Although there are reports about exosomes crossing the blood-brain …

Glioblastoma (GBM) as the most common primary malignant brain tumor exhibits a high
incidence and degree of malignancy as well as poor prognosis. Due to the existence of …

Focused ultrasound (FUS)-induced blood–brain barrier (BBB) opening is crucial for
enhancing glioblastoma (GBM) therapies. However, an in vivo imaging approach with a high …

Abstract Treatment of malignant glioma is a challenge facing cancer therapy. In addition to
surgery, and chemotherapy, radiotherapy (RT) is one of the most effective modalities of …

The precise assessment of vascular heterogeneity in brain tumors is vital for diagnosing,
grading, predicting progression, and guiding treatment decisions. However, currently, there …