The life of eukaryotic cells requires the transport of lipids between membranes, which are
separated by the aqueous environment of the cytosol. Vesicle-mediated traffic along the …

The endoplasmic reticulum (ER), which occupies a large portion of the cytoplasm, is the
cell's main site for the biosynthesis of lipids and carbohydrate conjugates, and it is essential …

Mitochondria, which are excluded from the secretory pathway, depend on lipid transport
proteins for their lipid supply from the ER, where most lipids are synthesized. In yeast, the …

To coordinate cellular physiology, eukaryotic cells rely on the rapid exchange of molecules
at specialized organelle–organelle contact sites,. Endoplasmic reticulum–mitochondrial …

The occurrence of protein mediated lipid transfer between intracellular membranes has
been known since the late 1960's. Since these early discoveries, numerous proteins …

The conserved VPS13 proteins constitute a new family of lipid transporters at membrane
contact sites. These large proteins are suspected to bridge membranes and form a direct …

The Endoplasmic Reticulum (ER) is an endomembrane system that plays a multiplicity of
roles in cell physiology and populates even the most distal cell compartments, including …

Cholesterol represents the most abundant single lipid in mammalian cells. How its
asymmetric distribution between subcellular membranes is achieved and maintained …

The endoplasmic reticulum (ER)-mitochondria contact site (ERMCS) is crucial for
exchanging biological molecules such as phospholipids and Ca2+ ions between these …

Membrane contact sites (MCSs) link organelles to coordinate cellular functions across space
and time. Although viruses remodel organelles for their replication cycles, MCSs remain …