Abstract Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) belongs to glycoside hydrolase
family 18. It binds to chitin, heparin, and hyaluronic acid, and is regulated by extracellular …

Abstract YKL-40, a chitinase-3-like protein 1 (CHI3L1) or human cartilage glycoprotein 39
(HC gp-39), is expressed and secreted by various cell-types including macrophages …

Over half of colorectal cancers (CRCs) harbor TP53 missense mutations (mutp53). We show
that the most common mutp53 allele R248Q (p53 Q) exerts gain of function (GOF) and …

Members of the 18 glycosyl hydrolase (GH 18) gene family have been conserved over
species and time and are dysregulated in inflammatory, infectious, remodeling, and …

Evasion of the immune response is a hallmark of cancer, and programmed cell death 1 (PD-
1) and PD-1 ligand 1 (PD-L1) are major mediators of this immunosuppression. Chitinase 3 …

Abstract Chitinase 3-like 1 (CHI3L1) is a secreted glycoprotein that mediates inflammation,
macrophage polarization, apoptosis, and carcinogenesis. The expression of CHI3L1 is …

Besides genetic polymorphisms and environmental factors, the intestinal microbiota is an
important factor in the etiology of Crohn's disease (CD). Among microbiota alterations, a …

Abstract Chitinase‐3‐like protein 1 (CHI3L1) is a secreted glycoprotein characterized by its
ability to regulate multiple biological processes, such as the inflammatory response and …

Abstract Chitinase 3-like 1 (CHI3L1), one of the mammalian members of the chitinase family,
is expressed in several types of human cancer, and elevated serum level of CHI3L1 is …

Chitinase-like proteins (CLPs) are lectins combining properties of cytokines and growth
factors. Human CLPs include YKL-40, YKL-39 and SI-CLP that are secreted by cancer cells …