In recent years, the occurrence of a wide variety of drug-resistant diseases has led to an
increase in interest in alternate therapies. Peptide-based drugs as an alternate therapy hold …

Solvent shielding of the amide hydrogen bond donor (NH groups) through chemical
modification or conformational control has been successfully utilized to impart membrane …

Since last century, peptides have emerged as potential drugs with> 90 FDA approvals for
various targets with several in the pipeline. Sulphur, in peptides is present either as thiol …

Thioamides represent highly valuable isosteric in the strictest sense “single‐atom
substitution” analogues of amides that have found broad applications in chemistry and …

Abstract The Psoralen (Pso) molecule finds extensive applications in photo‐chemotherapy,
courtesy of its triplet state forming ability. Sulfur and selenium replacement of exocyclic …

Environmentally friendly ynamide-mediated thioamidation of monothiocarboxylic acids with
amines or ammonium hydroxide for the syntheses of thioamides and primary thioamides is …

Many water-soluble polymers undergo phase separation above their lower critical solution
temperature (LCST) in aqueous solutions. Generally, the LCST is controlled via the polymer …

A novel thio-Ritter-type reaction of alkyl bromides, nitriles, and hydrogen sulfide has been
explored, providing a straightforward approach toward functionally important thioamides …

The thioamide is a naturally-occurring single atom substitution of the canonical amide bond.
The exchange of oxygen to sulfur alters the amide's physical and chemical characteristics …

Thioamide substitution of backbone peptide bonds can probe interactions along the main
chain of proteins. Despite theoretical predictions of the enhanced hydrogen bonding …