Neutrophil activated by the famous and potent PMA (Phorbol myristate acetate)
This review will briefly outline the major signaling pathways in PMA-activated neutrophils.
PMA is widely used to understand neutrophil pathways and formation of NETs. PMA …
PMA is widely used to understand neutrophil pathways and formation of NETs. PMA …
Master kinase PDK1 in tumorigenesis
N Zheng, J Wei, D Wu, Y Xu, J Guo - … et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
phosphoinositide-dependent protein kinase 1 (PDK1) is considered as master kinase
regulating AGC kinase family members such as AKT, SGK, PLK, S6K and RSK. Although …
regulating AGC kinase family members such as AKT, SGK, PLK, S6K and RSK. Although …
Longitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphoma
The mechanisms driving therapeutic resistance and poor outcomes of mantle cell lymphoma
(MCL) are incompletely understood. We characterize the cellular and molecular …
(MCL) are incompletely understood. We characterize the cellular and molecular …
D-cysteine is an endogenous regulator of neural progenitor cell dynamics in the mammalian brain
ER Semenza, MM Harraz… - Proceedings of the …, 2021 - National Acad Sciences
d-amino acids are increasingly recognized as important signaling molecules in the
mammalian central nervous system. However, the d-stereoisomer of the amino acid with the …
mammalian central nervous system. However, the d-stereoisomer of the amino acid with the …
MARCKS and MARCKS-like proteins in development and regeneration
Abstract Background The Myristoylated Alanine-Rich C-kinase Substrate (MARCKS) and
MARCKS-like protein 1 (MARCKSL1) have a wide range of functions, ranging from roles in …
MARCKS-like protein 1 (MARCKSL1) have a wide range of functions, ranging from roles in …
The TRPV4 agonist GSK1016790A regulates the membrane expression of TRPV4 channels
S Baratchi, P Keov, WG Darby, A Lai… - Frontiers in …, 2019 - frontiersin.org
TRPV4 is a non-selective cation channel that tunes the function of different tissues including
the vascular endothelium, lung, chondrocytes, and neurons. GSK1016790A is the selective …
the vascular endothelium, lung, chondrocytes, and neurons. GSK1016790A is the selective …
Conventional protein kinase C in the brain: 40 years later
JA Callender, AC Newton - Neuronal signaling, 2017 - portlandpress.com
Protein kinase C (PKC) is a family of enzymes whose members transduce a large variety of
cellular signals instigated by the receptor-mediated hydrolysis of membrane phospholipids …
cellular signals instigated by the receptor-mediated hydrolysis of membrane phospholipids …
Single-molecule study reveals how receptor and ras synergistically activate PI3Kα and PIP3 signaling
Cellular pathways controlling chemotaxis, growth, survival, and oncogenesis are activated
by receptor tyrosine kinases and small G-proteins of the Ras superfamily that stimulate …
by receptor tyrosine kinases and small G-proteins of the Ras superfamily that stimulate …
Cell chirality regulates intercellular junctions and endothelial permeability
Cell chirality is a newly discovered intrinsic property of the cell, reflecting the bias of the cell
to polarize in the left-right axis. Despite increasing evidence on its substantial role in the …
to polarize in the left-right axis. Despite increasing evidence on its substantial role in the …
Myristoylated alanine-rich C kinase substrate (MARCKS): a multirole signaling protein in cancers
Emerging evidence implicates myristoylated alanine-rich C-kinase substrate (MARCKS), a
major substrate of protein kinase C (PKC), in a critical role for cancer development and …
major substrate of protein kinase C (PKC), in a critical role for cancer development and …