The mechanisms through which general anaesthetics, an extremely diverse group of drugs,
cause reversible loss of consciousness have been a long-standing mystery. Gradually, a …

Steady-state evoked potentials can be recorded from the human scalp in response to
auditory stimuli presented at rates between 1 and 200 Hz or by periodic modulations of the …

Placing a patient in a state of general anesthesia is crucial for safely and humanely
performing most surgical and many nonsurgical procedures. How anesthetic drugs create …

Although general anaesthesia has been of tremendous importance for the development of
surgery, the underlying mechanisms by which this state is achieved are only just beginning …

Neuronal aggregates involved in conscious awareness are not evenly distributed
throughout the CNS but comprise key components referred to as the neural network …

General anesthesia consists of amnesia, hypnosis, analgesia, and areflexia. Of these, the
mechanism of hypnosis, or loss of consciousness, has been the most elusive, yet a …

The mechanisms underlying anesthesia-induced loss of consciousness remain a matter of
debate. Recent electrophysiological reports suggest that while initial propofol infusion …

Using functional magnetic resonance imaging (fMRI), we observed that noxious thermal
stimuli (46° C) produce significant signal change in putative reward circuitry as well as in …

While ubiquitous, pharmacological manipulation of consciousness remains poorly defined
and incompletely understood. This retards anesthetic drug development, confounds …

Objective: To examine whether a whole-body vibration (mechanical oscillations) in
comparison to a placebo administration leads to better postural control, mobility and balance …