Incretin drugs in diabetic kidney disease: biological mechanisms and clinical evidence

RZ Alicic, EJ Cox, JJ Neumiller, KR Tuttle - Nature Reviews Nephrology, 2021 - nature.com
As the prevalence of diabetes continues to climb, the number of individuals living with
diabetic complications will reach an unprecedented magnitude. The emergence of new …

The pathophysiology of hypertension in patients with obesity

VG DeMarco, AR Aroor, JR Sowers - Nature Reviews Endocrinology, 2014 - nature.com
The combination of obesity and hypertension is associated with high morbidity and mortality
because it leads to cardiovascular and kidney disease. Potential mechanisms linking …

Role of epicardial adipose tissue in cardiovascular diseases: a review

M Konwerski, A Gąsecka, G Opolski, M Grabowski… - Biology, 2022 - mdpi.com
Simple Summary Cardiovascular diseases (CVDs) are the leading causes of death
worldwide. Epicardial adipose tissue (EAT) is one of the most important risk factors for …

DPP4 and ACE2 in diabetes and COVID-19: therapeutic targets for cardiovascular complications?

I Valencia, C Peiro, O Lorenzo… - Frontiers in …, 2020 - frontiersin.org
COVID-19 outbreak, caused by severe acute respiratory syndrome (SARS)-CoV-2
coronavirus has become an urgent health and economic challenge. Diabetes is a risk factor …

Cellular mechanisms underlying obesity-induced arterial stiffness

AR Aroor, G Jia, JR Sowers - American Journal of …, 2018 - journals.physiology.org
Obesity is an emerging pandemic driven by consumption of a diet rich in fat and highly
refined carbohydrates (a Western diet) and a sedentary lifestyle in both children and adults …

Liraglutide causes large and rapid epicardial fat reduction

G Iacobellis, M Mohseni, SD Bianco, PK Banga - Obesity, 2017 - Wiley Online Library
Objective Epicardial adipose tissue (EAT), the visceral fat depot of the heart, is a modifiable
cardiovascular risk factor and emerging therapeutic target. Liraglutide, an analog of …

The role of tissue renin-angiotensin-aldosterone system in the development of endothelial dysfunction and arterial stiffness

AR Aroor, VG DeMarco, G Jia, Z Sun… - Frontiers in …, 2013 - frontiersin.org
Epidemiological studies support the notion that arterial stiffness is an independent predictor
of adverse cardiovascular events contributing significantly to systolic hypertension, impaired …

Hypoxia: the force that drives chronic kidney disease

Q Fu, SP Colgan, CS Shelley - Clinical medicine & research, 2016 - Marshfield Clinic
In the United States the prevalence of end-stage renal disease (ESRD) reached epidemic
proportions in 2012 with over 600,000 patients being treated. The rates of ESRD among the …

[HTML][HTML] Effects of a DPP-4 inhibitor and RAS blockade on clinical outcomes of patients with diabetes and COVID-19

SY Rhee, J Lee, H Nam, DS Kyoung… - Diabetes & …, 2021 - synapse.koreamed.org
Background Dipeptidyl peptidase-4 inhibitor (DPP-4i) and renin-angiotensin system (RAS)
blockade are reported to affect the clinical course of coronavirus disease 2019 (COVID-19) …

Epicardial fat: a new cardiovascular therapeutic target

G Iacobellis - Current opinion in pharmacology, 2016 - Elsevier
Highlights•Epicardial fat can be easily measured with imaging procedures.•Epicardial fat
can be a therapeutic target of drugs targeting the adipose tissue.•Epicardial fat responds to …