Abstract The epithelial Na+ channel (ENaC) transports Na+ across tight epithelia, including
the distal nephron. Different paradigms of ENaC regulation include extrinsic and intrinsic …

The kidney plays an essential role in blood pressure regulation by controlling short-term and
long-term NaCl and water balance. The thick ascending limb of the loop of Henle (TAL) …

The epithelial Na+ channel (ENaC) is a major regulator of salt and water reabsorption in a
number of epithelial tissues. Abnormalities in ENaC function have been directly linked to …

Dietary salt intake controls epithelial Na+ channel (ENaC)-mediated Na+ reabsorption in the
distal nephron by affecting status of the renin-angiotensin-aldosterone system (RAAS) …

The aldosterone-sensitive distal nephron (ASDN) includes the late distal convoluted tubule
2, the connecting tubule (CNT) and the collecting duct. The appropriate regulation of sodium …

The epithelial Na+ channel (ENaC) is a major regulator of salt and water reabsorption in a
number of epithelial tissues. Abnormalities in ENaC function have been directly linked to …

In contrast to constitutive secretion, SNARE‐mediated synaptic vesicle fusion is controlled
by multiple regulatory proteins, which determine the Ca2+ sensitivity of the vesicle fusion …

Studies of epithelial ion and fluid transport across the distal pulmonary epithelia have
provided important new concepts regarding the resolution of pulmonary edema, specifically …

The interaction of ion channels with the actin-based cytoskeleton in epithelial cells not only
maintains the polarized expression of ion channels within specific membrane domains, it …

The epithelial sodium channel (ENaC) is ubiquitinated by the E3 ligase Nedd4-2 at the
apical membranes of polarized cortical collecting duct (CCD) epithelial cells. This leads to …