A comprehensive review on factors influences biogenesis, functions, therapeutic and clinical implications of exosomes

S Gurunathan, MH Kang, JH Kim - International journal of …, 2021 - Taylor & Francis
Exosomes are nanoscale-sized membrane vesicles secreted by almost all cell types into the
extracellular environment upon fusion of multivesicular bodies and plasma membrane …

Mesenchymal stem cell-based therapy for cardiovascular disease: progress and challenges

L Bagno, KE Hatzistergos, W Balkan, JM Hare - Molecular Therapy, 2018 - cell.com
Administration of mesenchymal stem cells (MSCs) to diseased hearts improves cardiac
function and reduces scar. These effects occur via stimulation of endogenous repair …

Safety and efficacy of the intravenous infusion of umbilical cord mesenchymal stem cells in patients with heart failure: a phase 1/2 randomized controlled trial …

J Bartolucci, FJ Verdugo, PL González… - Circulation …, 2017 - Am Heart Assoc
Rationale: Umbilical cord–derived mesenchymal stem cells (UC-MSC) are easily accessible
and expanded in vitro, possess distinct properties, and improve myocardial remodeling and …

Applying extracellular vesicles based therapeutics in clinical trials–an ISEV position paper

T Lener, M Gimona, L Aigner, V Börger… - Journal of …, 2015 - Taylor & Francis
Extracellular vesicles (EVs), such as exosomes and microvesicles, are released by different
cell types and participate in physiological and pathophysiological processes. EVs mediate …

Extracellular vesicles in renal disease

D Karpman, A Ståhl, I Arvidsson - Nature Reviews Nephrology, 2017 - nature.com
Extracellular vesicles, such as exosomes and microvesicles, are host cell-derived packages
of information that allow cell–cell communication and enable cells to rid themselves of …

Rebuilding the damaged heart: mesenchymal stem cells, cell-based therapy, and engineered heart tissue

S Golpanian, A Wolf, KE Hatzistergos… - Physiological …, 2016 - journals.physiology.org
Mesenchymal stem cells (MSCs) are broadly distributed cells that retain postnatal capacity
for self-renewal and multilineage differentiation. MSCs evade immune detection, secrete an …

[HTML][HTML] Exosomal therapy—A new frontier in regenerative medicine

S Muthu, A Bapat, R Jain, N Jeyaraman… - Stem Cell …, 2021 - ncbi.nlm.nih.gov
The recent advances in translational and nanomedicine have paved the way for developing
the targeted drug delivery system at a greater pace among global researchers. On par with …

Mesenchymal stromal cell-derived extracellular vesicles protect the fetal brain after hypoxia-ischemia

DRMG Ophelders, TGAM Wolfs… - Stem cells …, 2016 - academic.oup.com
Preterm neonates are susceptible to perinatal hypoxic-ischemic brain injury, for which no
treatment is available. In a preclinical animal model of hypoxic-ischemic brain injury in ovine …

Enhanced proangiogenic potential of mesenchymal stem cell-derived exosomes stimulated by a nitric oxide releasing polymer

W Du, K Zhang, S Zhang, R Wang, Y Nie, H Tao, Z Han… - Biomaterials, 2017 - Elsevier
Mesenchymal stem cell (MSC)-derived exosomes have been recognized as new candidates
for the treatment of degenerative diseases or injury and may provide an alternative to cell …

Three decades of research on angiogenin: a review and perspective

J Sheng, Z Xu - Acta Biochim Biophys Sin, 2016 - academic.oup.com
As a member of the vertebrate-specific secreted ribonucleases, angiogenin (ANG) was first
isolated and identified solely by its ability to induce new blood vessel formation, and now, it …