Beyond the channel: metabotropic signaling by nicotinic receptors

N Kabbani, RA Nichols - Trends in pharmacological sciences, 2018 - cell.com
The α7 nicotinic acetylcholine receptor (nAChR) is a ligand-gated ion channel (LGIC) that
plays an important role in cellular calcium signaling and contributes to several neurological …

The expanding roles of Gβγ subunits in G protein–coupled receptor signaling and drug action

SM Khan, R Sleno, S Gora, P Zylbergold… - Pharmacological …, 2013 - Elsevier
Gβγ subunits from heterotrimeric G proteins perform a vast array of functions in cells with
respect to signaling, often independently as well as in concert with Gα subunits. However …

The Concise Guide to PHARMACOLOGY 2013/14: ion channels

SPH Alexander, HE Benson… - British journal of …, 2013 - Wiley Online Library
Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Identification and characterization of a G protein-binding cluster in α7 nicotinic acetylcholine receptors

JR King, JC Nordman, SP Bridges, MK Lin… - Journal of Biological …, 2015 - ASBMB
α7 nicotinic acetylcholine receptors (nAChRs) play an important role in synaptic
transmission and inflammation. In response to ligands, this receptor channel opens to …

[HTML][HTML] Structure and dynamics of differential ligand binding in the human ρ-type GABAA receptor

J Cowgill, C Fan, N Haloi, V Tobiasson, Y Zhuang… - Neuron, 2023 - cell.com
The neurotransmitter γ-aminobutyric acid (GABA) drives critical inhibitory processes in and
beyond the nervous system, partly via ionotropic type-A receptors (GABA A Rs) …

Are nicotinic acetylcholine receptors coupled to G proteins?

N Kabbani, JC Nordman, BA Corgiat, DP Veltri… - …, 2013 - Wiley Online Library
It was, until recently, accepted that the two classes of acetylcholine (ACh) receptors are
distinct in an important sense: muscarinic ACh receptors signal via heterotrimeric GTP …

Glycine as a neurotransmitter in the forebrain: a short review

MS Hernandes, LRP Troncone - Journal of neural transmission, 2009 - Springer
Since the late 1970s glycine has been considered an important inhibitory neurotransmitter in
brain stem and medulla. The description of its involvement in the mechanism of action of the …

AG protein‐coupled α7 nicotinic receptor regulates signaling and TNF‐α release in microglia

JR King, TC Gillevet, N Kabbani - FEBS Open Bio, 2017 - Wiley Online Library
Acetylcholine activation of α7 nicotinic acetylcholine receptors (α7 nAChR s) in microglia
attenuates neuroinflammation and regulates TNF‐α release. We used lipopolysaccharide to …

Homer1a-dependent crosstalk between NMDA and metabotropic glutamate receptors in mouse neurons

F Bertaso, G Roussignol, P Worley, J Bockaert, L Fagni… - PloS one, 2010 - journals.plos.org
Background A large number of evidences suggest that group-I metabotropic glutamate
receptors (mGluR1a, 1b, 1c, 5a, 5b) can modulate NMDA receptor activity. Interestingly, a …

The glycine receptor—a functionally important primary brain target of ethanol

B Söderpalm, HH Lidö, M Ericson - Alcoholism: Clinical and …, 2017 - Wiley Online Library
Identification of ethanol's (EtOH) primary molecular brain targets and determination of their
functional role is an ongoing, important quest. Pentameric ligand‐gated ion channels, that is …