Copper (I)-catalyzed 1, 3-dipolar cycloaddition between organic azides and terminal
alkynes, commonly known as CuAAC or click chemistry, has been identified as one of the …

Cu (I)-catalyzed azide–alkyne 1, 3-dipolar cycloaddition (CuAAC), popularly known as the
“click reaction”, serves as the most potent and highly dependable tool for facile construction …

Fluorescent antimicrobial peptides are promising structures for in situ, real-time imaging of
fungal infection. Here we report a fluorogenic probe to image Aspergillus fumigatus directly …

This Review is devoted to the chemistry of macrocyclic peptides having heterocyclic
fragments in their structure. These motifs are present in many natural products and synthetic …

Amanitin-based ADCs represent a new class of ADCs using a novel mode of action. This
payload introduces a novel mode of action into oncology therapy, the inhibition of RNA …

α-Amanitin is an extremely toxic bicyclic octapeptide isolated from the death-cap mushroom,
Amanita phalloides. As a potent inhibitor of RNA polymerase II, α-amanitin is toxic to …

The toxic bicyclic octapeptide α‐amanitin is mostly found in different species of the
mushroom genus Amanita, with the death cap (Amanita phalloides) as one of the most …

Fluorescent peptides are valuable tools for live-cell imaging because of the high specificity
of peptide sequences for their biomolecular targets. When preparing fluorescent versions of …

Abstract α‐Amanitin and related amatoxins have been studied for more than six decades
mostly by isolation from death cap mushrooms. The total synthesis, however, remained …

Natural products are the most effective source of potential drug leads. The total synthesis of
bioactive natural products plays a crucial role in confirming the hypothetical complex …