[HTML][HTML] Lessons from the past and charting the future of marine natural products drug discovery and chemical biology

WH Gerwick, BS Moore - Chemistry & biology, 2012 - cell.com
Marine life forms are an important source of structurally diverse and biologically active
secondary metabolites, several of which have inspired the development of new classes of …

The relevance of higher plants in lead compound discovery programs

AD Kinghorn, L Pan, JN Fletcher… - Journal of natural …, 2011 - ACS Publications
Along with compounds from terrestrial microorganisms, the constituents of higher plants
have provided a substantial number of the natural product-derived drugs used currently in …

The continuing search for antitumor agents from higher plants

L Pan, H Chai, AD Kinghorn - Phytochemistry Letters, 2010 - Elsevier
Plant secondary metabolites and their semi-synthetic derivatives continue to play an
important role in anticancer drug therapy. In this short review, selected single chemical entity …

Cytotoxic and antioxidant marine prenylated quinones and hydroquinones

SN Sunassee, MT Davies-Coleman - Natural Product Reports, 2012 - pubs.rsc.org
Covering: 1972 to 2011 This review covers the literature of prenylated quinone,
hydroquinone and naphthoquinone marine natural products with reported cytotoxic and/or …

Highlights of marine invertebrate-derived biosynthetic products: Their biomedical potential and possible production by microbial associants

OK Radjasa, YM Vaske, G Navarro, HC Vervoort… - Bioorganic & medicinal …, 2011 - Elsevier
Coral reefs are among the most productive marine ecosystems and are the source of a large
group of structurally unique biosynthetic products. Annual reviews of marine natural …

Phytochemicals in anticancer drug development

R Dutt, V Garg, N Khatri… - Anti-Cancer Agents in …, 2019 - ingentaconnect.com
Background: In spite of major technological advances in conventional therapies, cancer
continues to remain the leading cause of mortality worldwide. Phytochemicals are gradually …

Application of diffusion growth chambers for the cultivation of marine sponge-associated bacteria

G Steinert, S Whitfield, MW Taylor, C Thoms… - Marine …, 2014 - Springer
Marine sponges contain dense and diverse microbial communities, which are renowned as
a source of bioactive metabolites. The biological activities of sponge-microbe natural …

Cultivation of sponges, sponge cells and symbionts: achievements and future prospects

KJ Schippers, D Sipkema, R Osinga, H Smidt… - Advances in marine …, 2012 - Elsevier
Marine sponges are a rich source of bioactive compounds with pharmaceutical potential.
Since biological production is one option to supply materials for early drug development, the …

[PDF][PDF] 海洋真菌生物活性物质研究之管见

朱伟明, 王俊锋 - 菌物学报, 2011 - researchgate.net
海洋真菌生物活性物质研究之管见 Page 1 Mycosystema 菌物学报15 March 2011, 30(2): 218-228
jwxt@im.ac.cn ISSN1672-6472 CN11-5180Q ©2011 Institute of Microbiology, CAS, all rights …

A review of pharmacological and toxicological potentials of marine cyanobacterial metabolites

M Nagarajan, V Maruthanayagam… - Journal of Applied …, 2012 - Wiley Online Library
Novel toxic metabolites from marine cyanobacteria have been thoroughly explored.
Biologically active and chemically diverse compounds that could be hepatotoxic, neurotoxic …