The application of scaffolding materials is believed to hold enormous potential for tissue
regeneration. Despite the widespread application and rapid advance of several tissue …

To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME),
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …

Tissue engineering is essentially a technique for imitating nature. Natural tissues are made
up of three parts: extracellular matrix (ECM), signaling systems, and cells. Therefore …

Bioengineering an in vitro liver model recapitulating the native liver microarchitecture
consisting of parenchymal and non-parenchymal cells is crucial in achieving cellular …

The regenerative function of liver can be destroyed by viral infection, drug poisoning and
tumorigenesis, resulting in irreversible damage. Numerous approaches in promoting liver …

Seriously compromised function of some organs can only be restored by transplantation.
Due to the shortage of human donors, the need to find another source of organs is of primary …

The process of tissue regeneration requires the utilization of a scaffold, which serves as a
structural framework facilitating cellular adhesion, proliferation, and migration within a …

Bi-dimensional culture systems have represented the most used method to study cell
biology outside the body for over a century. Although they convey useful information, such …

Liver plays a critical role in drug metabolism and nowadays multi-cellular culture systems
aiming at imitating liver-specific morphology and functionality are advancing robustly …

Drug-induced liver injury (DILI) is one of the leading causes of clinical trial failures and high
drug attrition rates. Currently, the commonly used hepatocyte models include primary human …