Navigating for reward

M Sosa, LM Giocomo - Nature Reviews Neuroscience, 2021 - nature.com
An organism's survival can depend on its ability to recall and navigate to spatial locations
associated with rewards, such as food or a home. Accumulating research has revealed that …

The physiological control of eating: signals, neurons, and networks

AG Watts, SE Kanoski, G Sanchez-Watts… - Physiological …, 2022 - journals.physiology.org
During the past 30 yr, investigating the physiology of eating behaviors has generated a truly
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …

Genetic mapping of etiologic brain cell types for obesity

PN Timshel, JJ Thompson, TH Pers - Elife, 2020 - elifesciences.org
The underlying cell types mediating predisposition to obesity remain largely obscure. Here,
we integrated recently published single-cell RNA-sequencing (scRNA-seq) data from 727 …

Putting together pieces of the lateral septum: multifaceted functions and its neural pathways

CA Rizzi-Wise, DV Wang - ENeuro, 2021 - eneuro.org
The lateral septum (LS) is implicated as a hub that regulates a variety of affects, such as
reward, feeding, anxiety, fear, sociability, and memory. However, it remains unclear how the …

An orexigenic subnetwork within the human hippocampus

DAN Barbosa, S Gattas, JS Salgado, FM Kuijper… - Nature, 2023 - nature.com
Only recently have more specific circuit-probing techniques become available to inform
previous reports implicating the rodent hippocampus in orexigenic appetitive processing …

Non-canonical interplay between glutamatergic NMDA and dopamine receptors shapes synaptogenesis

N Bénac, G Ezequiel Saraceno, C Butler… - Nature …, 2024 - nature.com
Direct interactions between receptors at the neuronal surface have long been proposed to
tune signaling cascades and neuronal communication in health and disease. Yet, the lack of …

Memory and eating: A bidirectional relationship implicated in obesity

MB Parent, S Higgs, LG Cheke, SE Kanoski - … & Biobehavioral Reviews, 2022 - Elsevier
This paper reviews evidence demonstrating a bidirectional relationship between memory
and eating in humans and rodents. In humans, amnesia is associated with impaired …

Roles for the gut microbiota in regulating neuronal feeding circuits

BY Kristie, EY Hsiao - The Journal of clinical investigation, 2021 - Am Soc Clin Investig
The gut microbiota has the capacity to affect host appetite via intestinal satiety pathways, as
well as complex feeding behaviors. In this Review, we highlight recent evidence that the gut …

2-Ethylhexyl Diphenyl Phosphate Causes Obesity in Zebrafish by Stimulating Overeating via Inhibition of Dopamine Receptor D2

R Yang, Y Zhang, Y Deng, Y Yang… - … Science & Technology, 2023 - ACS Publications
Obesity is a popular public health problem worldwide and is mainly caused by overeating,
but little is known about the impacts of synthetic chemicals on obesity. Herein, we evaluated …

Identification of a GABAergic neural circuit governing leptin signaling deficiency-induced obesity

Y Han, Y He, L Harris, Y Xu, Q Wu - Elife, 2023 - elifesciences.org
The hormone leptin is known to robustly suppress food intake by acting upon the leptin
receptor (LepR) signaling system residing within the agouti-related protein (AgRP) neurons …