When mycophenolic acid (MPA) was originally marketed for immunosuppressive therapy,
fixed doses were recommended by the manufacturer. Awareness of the potential for a more …

Glucuronidation mediated by UDP-glucuronosyltransferases (UGTs) is a significant
metabolic pathway that facilitates efficient elimination of numerous endobiotics and …

Offering up-to-date, comprehensive coverage of disease progression, diagnosis,
management, and prognosis, Textbook of Pediatric Rheumatology is the definitive reference …

Microphysiological systems (MPS) consisting of multiple linked organ-on-a-chip (OoC)
components are highly promising tools with potential to provide more relevant in vitro to in …

Uridine-disphosphate glucuronosyl transferase (UGT) enzymes catalyze the formation of
glucuronide conjugates of phase II metabolism. Methods for absolute quantification of …

The goal of this study was to determine the roles of the organic anion–transporting
polypeptides (OATPs) OATP1A2, OATP1B1, and OATP1B3 and their genetic variants in the …

Although therapeutic drug monitoring (TDM) of immunosuppressive drugs has been an
integral part of routine clinical practice in solid organ transplantation for many years …

This article summarizes part of a consensus meeting about mycophenolate (MPA)
therapeutic drug monitoring held in Rome under the auspices of The Transplantation …

Bacterial β-glucuronidase enzymes (BGUSs) are at the interface of host-microbial metabolic
symbiosis, playing an important role in health and disease as well as medication outcomes …

With current treatment regimens, a relatively high proportion of transplant recipients
experience underimmunosuppression or overimmunosuppression. Recently, several …