The regulation of ferroptosis by tumor suppressor p53 and its pathway
Tumor suppressor p53 plays a key role in tumor suppression. In addition to tumor
suppression, p53 is also involved in many other biological and pathological processes, such …
suppression, p53 is also involved in many other biological and pathological processes, such …
The dipeptidyl peptidase family, prolyl oligopeptidase, and prolyl carboxypeptidase in the immune system and inflammatory disease, including atherosclerosis
Y Waumans, L Baerts, K Kehoe, AM Lambeir… - Frontiers in …, 2015 - frontiersin.org
Research from over the past 20 years has implicated dipeptidyl peptidase (DPP) IV and its
family members in many processes and different pathologies of the immune system. Most …
family members in many processes and different pathologies of the immune system. Most …
The tumor suppressor p53 limits ferroptosis by blocking DPP4 activity
Ferroptosis is a form of regulated cell death that may facilitate the selective elimination of
tumor cells. The tumor suppressor p53 (TP53) has been demonstrated to promote …
tumor cells. The tumor suppressor p53 (TP53) has been demonstrated to promote …
Co-culture of tumor spheroids and fibroblasts in a collagen matrix-incorporated microfluidic chip mimics reciprocal activation in solid tumor microenvironment
Multicellular 3D culture and interaction with stromal components are considered essential
elements in establishing a 'more clinically relevant'tumor model. Matrix-embedded 3D …
elements in establishing a 'more clinically relevant'tumor model. Matrix-embedded 3D …
Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1–based therapies
M Elashoff, AV Matveyenko, B Gier, R Elashoff… - Gastroenterology, 2011 - Elsevier
BACKGROUND & AIMS: Glucagon-like peptide-1− based therapy is gaining widespread
use for type 2 diabetes, although there are concerns about risks for pancreatitis and …
use for type 2 diabetes, although there are concerns about risks for pancreatitis and …
Cancer exosomes express CD39 and CD73, which suppress T cells through adenosine production
Extracellular adenosine is elevated in cancer tissue, and it negatively regulates local
immune responses. Adenosine production from extracellular ATP has attracted attention as …
immune responses. Adenosine production from extracellular ATP has attracted attention as …
A subpopulation of CD26+ cancer stem cells with metastatic capacity in human colorectal cancer
Recent evidence suggests that a subpopulation of cancer cells, cancer stem cells (CSCs), is
responsible for tumor growth in colorectal cancer. However, the role of CSCs in colorectal …
responsible for tumor growth in colorectal cancer. However, the role of CSCs in colorectal …
Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice
AM Santos, J Jung, N Aziz, JL Kissil… - The Journal of clinical …, 2009 - Am Soc Clin Investig
Membrane-bound proteases have recently emerged as critical mediators of tumorigenesis,
angiogenesis, and metastasis. However, the mechanisms by which they regulate these …
angiogenesis, and metastasis. However, the mechanisms by which they regulate these …
CD26/DPP4-a potential biomarker and target for cancer therapy
N Enz, G Vliegen, I De Meester… - Pharmacology & …, 2019 - Elsevier
Abstract CD26/dipeptidyl peptidase (DPP) 4 is a membrane-bound protein found in many
cell types of the body, and a soluble form is present in body fluids. There is longstanding …
cell types of the body, and a soluble form is present in body fluids. There is longstanding …
Dipeptidyl peptidase-4 (CD26): knowing the function before inhibiting the enzyme
E Matteucci, O Giampietro - Frontiers in Medicinal Chemistry …, 2016 - benthamdirect.com
Dipeptidyl peptidase-4 (DPP4) or adenosine deaminase complexing protein 2 (ADCP 2) or
T-cell activation antigen CD26 (EC 3.4. 14.5.) is a serine exopeptidase belonging to the S9B …
T-cell activation antigen CD26 (EC 3.4. 14.5.) is a serine exopeptidase belonging to the S9B …