Cytokines are major drivers of autoimmunity, and biologic agents targeting cytokines have
revolutionized the treatment of immune-mediated diseases. Despite the effectiveness of …

Cytokines are small secreted proteins released by different types of cells with specific effects
on cellular signaling and communication via binding to their receptors on the cell surface. IL …

Abstract Purpose of Review Chronic non-bacterial osteomyelitis (CNO) with its most severe
form chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone …

Inflammation is a pivotal response to a variety of stimuli, and inflammatory molecules such
as cytokines have central roles in the pathogenesis of various diseases, including bone and …

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by multi-articular,
symmetrical and invasive arthritis resulting from immune system abnormalities involving T …

We investigated the potential involvement of pyroptosis, a proinflammatory form of regulated
cell death, in rheumatoid arthritis (RA). Synovial fluid, synovial tissues and/or serum were …

Inflammasomes are cytosolic polyprotein complexes formed in response to various external
and internal stimuli, including viral and bacterial antigens. The main product of the …

While the molecular mechanisms promoting activation of the Nod-like Receptor (NLR) family
member NLRP3 inflammasome are beginning to be defined, little is known about the …

Inflammasomes are a multi-protein platform forming a part of the innate immune system.
Inflammasomes are at standby status and can be activated when needed. Inflammasome …

Transplantation of allogeneic adult spinal cord tissues (aSCTs) to replace the injured spinal
cord, serves as a promising strategy in complete spinal cord injury (SCI) repair. However, in …