Acute myeloid leukemia (AML) is a malignant tumor of the immature myeloid hematopoietic
cells in the bone marrow (BM). It is a highly heterogeneous disease, with rising morbidity …

Normal hematopoiesis requires the accurate orchestration of lineage-specific patterns of
gene expression at each stage of development, and epigenetic regulators play a vital role …

Hematopoiesis requires finely tuned regulation of gene expression at each stage of
development. The regulation of gene transcription involves not only individual transcription …

Background Microglial activation-mediated neuroinflammation is a major contributor to early
brain injury (EBI) after subarachnoid hemorrhage (SAH). MicroRNA-124 (miR-124) is the …

Early-stage detection of leukemia is a critical determinant for successful treatment of the
disease and can increase the survival rate of leukemia patients. The factors limiting the …

The AML1-ETO fusion protein (A/E), which results from the t (8; 21) translocation, is
considered to be a leukemia-initiating event. Identifying the mechanisms underlying the …

Posttranscriptional regulation has emerged as a driver for leukemia development and an
avenue for therapeutic targeting. Among posttranscriptional processes, alternative …

This work aims to elucidate the effects and the potential underlying mechanisms of
microRNA-216a-3p (miR-216a-3p) on the proliferation, migration, and invasion of gastric …

MicroRNAs (miRNAs) play key roles in the pathogenesis of many cancers, including acute
myeloid leukemia (AML). Although miRNA-9 (miR-9) is involved in the leukemogenesis of …

Myelopoiesis is a complex process driven by essential transcription factors, including
C/EBPα, PU. 1, RUNX1, KLF4 and IRF8. Together, these factors are critical for the control of …