In recent years, tumor immunotherapy has made significant progress. However, tumor
immunotherapy, particularly immune checkpoint inhibitors (eg, PD-1/PD-L1 inhibitors) …

Tumor-associated macrophages (TAMs) are abundant, nearly accounting for 30–50% of
stromal cells in the tumor microenvironment. TAMs exhibit an immunosuppressive M2-like …

Macrophages are crucial drivers of tumour-promoting inflammation. Tumour-associated
macrophages (TAMs) contribute to tumour progression at different levels: by promoting …

Reprogramming the immunosuppressive tumor microenvironment by modulating
macrophages holds great promise in tumor immunotherapy. As a class of professional …

Macrophages are a major component of the tumor microenvironment and orchestrate
various aspects of immunity. Within tumors, macrophages can reversibly alter their endotype …

Bone metastases are a frequent and severe complication of advanced-stage cancers. Breast
and prostate cancers, the most common malignancies in women and men, respectively …

As an essential innate immune population for maintaining body homeostasis and warding
off foreign pathogens, macrophages display high plasticity and perform diverse supportive …

Macrophages are key cellular components of the innate immunity, acting as the main player
in the first‐line defence against the pathogens and modulating homeostatic and …

Osteosarcomas (OSs) are bone tumors most commonly found in pediatric and adolescent
patients characterized by high risk of metastatic progression and recurrence after therapy …

The critical role of angiogenesis in promoting tumor growth and metastasis is strongly
established. However, tumors show considerable variation in angiogenic characteristics and …