Inflammation is an evolutionarily selected defense response to infection or tissue damage
that involves activation and consumption of immune cells in order to reestablish and …

All hematopoietic and immune cells are continuously generated by hematopoietic stem cells
(HSCs) and hematopoietic progenitor cells (HPCs) through highly organized process of …

Bacterial infection leads to consumption of short-lived innate immune effector cells, which
then need to be replenished from hematopoietic stem and progenitor cells (HSPCs). HSPCs …

Innate myeloid immune cells, and neutrophils in particular, serve as first line of defense
against pathogenic microorganisms including bacteria and fungi. Given their short life span …

Hematopoietic stem cells (HSC) reside in the bone marrow (BM) within a specialized micro-
environment, the HSC niche, which comprises several cellular constituents. These include …

Hematopoietic stem cells (HSCs) produce highly diverse cell lineages. Here, we chart native
lineage pathways emanating from HSCs and define their physiological regulation by …

Chronic viral infections are associated with hematopoietic suppression, bone marrow (BM)
failure, and hematopoietic stem cell (HSC) exhaustion. However, how persistent viral …

Angiogenesis, hematopoiesis and osteogenesis are fundamental processes mediating
complex and essential biological functions. In the bone marrow, endothelial cells (ECs) are …

Extramedullary hematopoiesis (EMH) is the expansion and differentiation of hematopoietic
stem and progenitor cells outside of the bone marrow. In postnatal life, as a compensatory …

Despite numerous observations linking protracted exposure to low-dose (LD) radiation and
leukemia occurrence, the effects of LD irradiation on hematopoietic stem cells (HSCs) …