Metformin is a well-known anti-diabetic drug that has been repurposed for several emerging
applications, including as an anti-cancer agent. It boasts the distinct advantages of an …

Metformin is a widely used drug in today's prescriptions by physicians due to its specific
effects in treating and curing type II diabetes. Diabetes is a common disease that may occur …

Betulin, a pentacyclic triterpene and a plant pentacyclic triterpene metabolite, can be found
in large quantities in the outer bark of the birches (Betula, Betulaceae). Betulinic acid …

The clonogenic assay measures the capacity of single cells to form colonies in vitro. It is
widely used to identify and quantify self-renewing mammalian cells derived from in vitro …

Epidemiologic evidence suggests that cancer incidence is associated with diabetes as well
as certain diabetes risk factors and treatments. This consensus statement of experts …

Background Metformin is a commonly used drug for the treatment of diabetes. Accumulating
evidence suggests that it exerts anti-tumor effects in many cancers, including multiple …

Weight, weight gain, and obesity account for approximately 20% of all cancer cases.
Evidence on the relation of each to cancer is summarized, including esophageal, thyroid …

Metformin, an insulin-lowering agent, has been associated with decreased cancer risk in
epidemiologic studies in diabetic patients. We performed a comprehensive literature search …

Diabetes and cancer are two heterogeneous, multifactorial, severe, and chronic diseases.
Because of their frequency, reciprocal influences–even minor influences–may have a major …

The cancer stem cell hypothesis suggests that, unlike most cancer cells within a tumor,
cancer stem cells resist chemotherapeutic drugs and can regenerate the various cell types …