This paper provides a review of engineering applications and computational methods used
to analyze the dynamics of heart valve closures in healthy and diseased states …

The leaflets of the atrioventricular heart valves (AHVs) regulate the one-directional flow of
blood through a coordination of the extracellular matrix components, including the collagen …

The pre-strains of biological soft tissues are important when relating their in vitro and in vivo
mechanical behaviors. In this study, we present the first-of-its-kind experimental …

Natural cellular structures inspire numerous engineering applications due to their
lightweight and good load-bearing capabilities. Variations in their structural configurations …

Commercial finite element modeling packages do not have the tools necessary to effectively
incorporate the complex anisotropic and heterogeneous material properties typical of the …

Mechanical characterization of the ex vivo tricuspid valve (TV) continues to provide key
insights into native valve function and the development of valvular diseases. However …

Skin undergoes mechanical alterations due to changes in the composition and structure of
the collagenous dermis with aging. Previous studies have conflicting findings, with both …

The biased use of male subjects in biomedical research has created limitations,
underscoring the importance of including women to enhance the outcomes of evidence …

Sclera collagen fiber microstructure and mechanical behavior are central to eye physiology
and pathology. They are also complex, and are therefore often studied using modeling. Most …

Collagen is the main load-bearing component of cornea and sclera. When stretched, both of
these tissues exhibit a behavior known as collagen fiber recruitment. In recruitment, as the …