Enteric nervous system development: migration, differentiation, and disease

JI Lake, RO Heuckeroth - American Journal of Physiology …, 2013 - journals.physiology.org
The enteric nervous system (ENS) provides the intrinsic innervation of the bowel and is the
most neurochemically diverse branch of the peripheral nervous system, consisting of two …

[HTML][HTML] The enteric nervous system

V Sasselli, V Pachnis, AJ Burns - Developmental biology, 2012 - Elsevier
The enteric nervous system (ENS), the intrinsic innervation of the gastrointestinal tract,
consists of numerous types of neurons, and glial cells, that are distributed in two …

Development and developmental disorders of the enteric nervous system

F Obermayr, R Hotta, H Enomoto… - Nature reviews …, 2013 - nature.com
The enteric nervous system (ENS) arises from neural crest-derived cells that migrate into
and along the gut, leading to the formation of a complex network of neurons and glial cells …

Building a second brain in the bowel

M Avetisyan, EM Schill… - The Journal of clinical …, 2015 - Am Soc Clin Investig
The enteric nervous system (ENS) is sometimes called the “second brain” because of the
diversity of neuronal cell types and complex, integrated circuits that permit the ENS to …

Development of enteric neuron diversity

MM Hao, HM Young - Journal of cellular and molecular …, 2009 - Wiley Online Library
Neuronal diversity in the adult enteric nervous system (ENS)• Developmental appearance
and birthdating of enteric neuron subtypes and glial cells‐Developmental appearance of …

Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling

B Beirowski, J Gustin, SM Armour… - Proceedings of the …, 2011 - National Acad Sciences
The formation of myelin by Schwann cells (SCs) occurs via a series of orchestrated
molecular events. We previously used global expression profiling to examine peripheral …

Blockage of GSK3β-mediated Drp1 phosphorylation provides neuroprotection in neuronal and mouse models of Alzheimer's disease

J Yan, XH Liu, MZ Han, YM Wang, XL Sun, N Yu… - Neurobiology of …, 2015 - Elsevier
It is well established that mitochondrial fragmentation plays a key role in the pathogenesis of
Alzheimer's disease (AD). Mitochondrial fission is mediated by dynamin-related protein 1 …

Neuronal polarity: demarcation, growth and commitment

A Cáceres, B Ye, CG Dotti - Current opinion in cell biology, 2012 - Elsevier
In a biological sense, polarity refers to the extremity of the main axis of an organelle, cell, or
organism. In neurons, morphological polarity begins with the appearance of the first neurite …

The role of small GTPases in neuronal morphogenesis and polarity

C Gonzalez‐Billault, P Muñoz‐Llancao… - …, 2012 - Wiley Online Library
The highly dynamic remodeling and cross talk of the microtubule and actin cytoskeleton
support neuronal morphogenesis. Small RhoGTPases family members have emerged as …

[HTML][HTML] Enteric nervous system assembly: Functional integration within the developing gut

MM Hao, JPP Foong, JC Bornstein, ZL Li… - Developmental …, 2016 - Elsevier
Co-ordinated gastrointestinal function is the result of integrated communication between the
enteric nervous system (ENS) and “effector” cells in the gastrointestinal tract. Unlike smooth …