This article comprises detailed information about L-asparaginase, encompassing topics
such as microbial and plant sources of L-asparaginase, treatment with L-asparaginase …

Innovative drug delivery technologies are key components of drug development, with
commercial and intellectual values. PEGylation is an excellent example of a delivery system …

Poly (ethylene glycol)-conjugated (or PEGylated) proteins are an increasingly important
class of therapeutic proteins that offer improved in vivo circulation half lives over their …

As pharmaceutical companies strive to develop safer medicines at a lower cost, they must
keep pace with the rapid growth of technology and research methodologies. Defying the …

Covalent attachment of poly (ethylene) glycol (PEG) groups to proteins, a process commonly
called PEGylation, is often used to improve the performance of a protein in vivo. To date, at …

Polymer modified pharmaceuticals represent an important and growing family of
pharmaceuticals. However, there is, as yet, no method-of-choice process for their …

Bacterial L-ASNases (l-asparaginases) catalyse the conversion of l-asparagine into l-
aspartate and ammonia, and are widely used for the treatment of ALL (acute lymphoblastic …

Microspheres and microcapsules have very broad applications in various fields, especially
in those of biotechnology and biopharmaceuticals, as targeting drug–delivery carriers …

The production of antileukemic enzyme l-asparaginase in two distinctly related bacteria,
Enterobacter aerogenes, Pseudomonas aeruginosa, and in their recombinants expressing …

The combination of PEG–protein conjugation and chromatographic separation is generally
known as solid-phase or on-column PEGylation and can provide advantages compared to …