Synthetic extracellular matrices with function-encoding peptides

C Ligorio, A Mata - Nature reviews bioengineering, 2023 - nature.com
The communication of cells with their surroundings is mostly encoded in the epitopes of
structural and signalling proteins present in the extracellular matrix (ECM). These peptide …

Multicomponent peptide assemblies

DM Raymond, BL Nilsson - Chemical Society Reviews, 2018 - pubs.rsc.org
Self-assembled peptide nanostructures have been increasingly exploited as functional
materials for applications in biomedicine and energy. The emergent properties of these …

Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review

P Csermely, T Korcsmáros, HJM Kiss, G London… - Pharmacology & …, 2013 - Elsevier
Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

Self‐assembly in nature: using the principles of nature to create complex nanobiomaterials

AC Mendes, ET Baran, RL Reis… - Wiley interdisciplinary …, 2013 - Wiley Online Library
Self‐assembly is a ubiquitous process in biology where it plays numerous important roles
and underlies the formation of a wide variety of complex biological structures. Over the past …

Insights into low molecular mass organic gelators: a focus on drug delivery and tissue engineering applications

KJ Skilling, F Citossi, TD Bradshaw, M Ashford… - Soft matter, 2014 - pubs.rsc.org
In recent years low molecular mass organic gelators (LMOGs) have gained increasing
interest as an alternative biomaterial to polymer derived gels, with potential applications in …

Self-assembling peptide scaffolds for regenerative medicine

JB Matson, SI Stupp - Chemical communications, 2012 - pubs.rsc.org
Biomaterials made from self-assembling, short peptides and peptide derivatives have great
potential to generate powerful new therapies in regenerative medicine. The high signaling …

Moving from static to dynamic complexity in hydrogel design

JA Burdick, WL Murphy - Nature communications, 2012 - nature.com
Hydrogels are water-swollen polymer networks that have found a range of applications from
biological scaffolds to contact lenses. Historically, their design has consisted primarily of …

Advances in immunotherapy delivery from implantable and injectable biomaterials

DG Leach, S Young, JD Hartgerink - Acta biomaterialia, 2019 - Elsevier
Macroscale biomaterials, such as preformed implantable scaffolds and injectable soft
materials, possess powerful synergies with anti-cancer immunotherapies. Immunotherapies …

Gradated assembly of multiple proteins into supramolecular nanomaterials

GA Hudalla, T Sun, JZ Gasiorowski, H Han, YF Tian… - Nature materials, 2014 - nature.com
Biomaterials exhibiting precise ratios of different bioactive protein components are critical for
applications ranging from vaccines to regenerative medicine, but their design is often …

Recent advances in multicellular tumor spheroid generation for drug screening

KH Lee, TH Kim - Biosensors, 2021 - mdpi.com
Multicellular tumor spheroids (MCTs) have been employed in biomedical fields owing to
their advantage in designing a three-dimensional (3D) solid tumor model. For controlling …