To accommodate daily recurring environmental changes, animals show cyclic variations in
behaviour and physiology, which include prominent behavioural states such as sleep–wake …

Circadian rhythms play an influential role in nearly all aspects of physiology and behavior in
the vast majority of species on Earth. The biological clockwork that regulates these rhythms …

Sleep–wake cycles are known to be disrupted in people with neurodegenerative disorders.
These findings are now supported by data from animal models for some of these disorders …

Circadian disruption aggravates age-related decline and mortality. However, it remains
unclear whether circadian enhancement can retard aging in mammals. We previously …

Endogenous circadian clocks orchestrate several metabolic and signaling pathways that are
known to modulate lifespan, suggesting clocks as potential targets for manipulation of …

Defects in circadian rhythm influence physiology and behavior with implications for the
treatment of sleep disorders, metabolic disease, and cancer. Although core regulatory …

The immune system is built to counteract unpredictable threats, yet it relies on predictable
cycles of activity to function properly. Daily rhythms in immune function are an expanding …

Circadian timekeeping systems drive oscillatory gene expression to regulate essential
cellular and physiological processes. When the systems are perturbed, pathological …

A growing body of evidence suggests that meal timing is an important factor for metabolic
regulation and that the circadian clock tightly interacts with metabolic functions. The proper …

Astragalus polysaccharide (APS) is a notable bioactive component of Astragalus
membranaceus and has been extensively investigated for its pharmacological activities …