Synaptic targets: Chronic alcohol actions

M Roberto, FP Varodayan - Neuropharmacology, 2017 - Elsevier
Alcohol acts on numerous cellular and molecular targets to regulate neuronal
communication within the brain. Chronic alcohol exposure and acute withdrawal generate …

Neurobiology of alcohol seeking behavior

E Domi, A Domi, L Adermark, M Heilig… - Journal of …, 2021 - Wiley Online Library
Alcohol addiction is a chronic relapsing brain disease characterized by an impaired ability to
stop or control alcohol use despite adverse consequences. A main challenge of addiction …

The TMEM132B-GABAA receptor complex controls alcohol actions in the brain

G Wang, S Peng, MR Mendez, A Keramidas… - Cell, 2024 - cell.com
Alcohol is the most consumed and abused psychoactive drug globally, but the molecular
mechanisms driving alcohol action and its associated behaviors in the brain remain …

[PDF][PDF] The immunological function of GABAergic system

C Wu, X Qin, H Du, N Li, W Ren, Y Peng - Front Biosci, 2017 - article.imrpress.com
As a well-known inhibitory neurotransmitter in the central nervous system, gamma-
aminobutyric acid also has critical roles in immune system. Immune cells (eg, lymphocytes …

The evolution toward designer benzodiazepines in drug-facilitated sexual assault cases

M Pérez Orts, A van Asten… - Journal of Analytical …, 2023 - academic.oup.com
Drug-facilitated sexual assault (DFSA) is a crime where the victim is unable to provide
sexual consent due to incapacitation resulting from alcohol or drug consumption. Due to the …

The glycine receptor—a functionally important primary brain target of ethanol

B Söderpalm, HH Lidö, M Ericson - Alcoholism: Clinical and …, 2017 - Wiley Online Library
Identification of ethanol's (EtOH) primary molecular brain targets and determination of their
functional role is an ongoing, important quest. Pentameric ligand‐gated ion channels, that is …

Homocysteine, alcoholism, and its potential epigenetic mechanism

PK Kamat, CJ Mallonee, AK George… - Alcoholism: Clinical …, 2016 - Wiley Online Library
Alcohol is the most socially accepted addictive drug. Alcohol consumption is associated with
some health problems such as neurological, cognitive, behavioral deficits, cancer, heart …

Functional alternatives to alcohol

DJ Nutt, RJ Tyacke, M Spriggs, V Jacoby, AD Borthwick… - Nutrients, 2022 - mdpi.com
The consumption of alcohol is associated with well-known health harms and many
governments worldwide are actively engaged in devising approaches to reduce them. To …

[HTML][HTML] Humulone modulation of GABAA receptors and its role in hops sleep-promoting activity

AY Benkherouf, K Eerola, SL Soini… - Frontiers in …, 2020 - frontiersin.org
Humulus lupulus L.(hops) is a major constituent of beer. It exhibits neuroactive properties
that make it useful as a sleeping aid. These effects are hypothesized to be mediated by an …

Blood vessels as a key mediator for ethanol toxicity: implication for neuronal damage

K Nakayama, H Hasegawa - Life, 2022 - mdpi.com
Excessive intake of ethanol is associated with severe brain dysfunction, and the subsequent
neurological and behavioral abnormalities are well-established social risks. Many research …