The pathogenesis of obesity

SM Oussaada, KA Van Galen, MI Cooiman… - Metabolism, 2019 - Elsevier
Body fat mass increases when energy intake exceeds energy expenditure. In the long term,
a positive energy balance will result in obesity. The worldwide prevalence of obesity has …

Intranasal insulin

M Hallschmid - Journal of neuroendocrinology, 2021 - Wiley Online Library
The intranasal (IN) route enables the delivery of insulin to the central nervous system in the
relative absence of systemic uptake and related peripheral side effects. Intranasally …

Hypothalamic detection of macronutrients via multiple gut-brain pathways

N Goldstein, AD McKnight, JRE Carty, M Arnold… - Cell metabolism, 2021 - cell.com
Food intake is tightly regulated by complex and coordinated gut-brain interactions. Nutrients
rapidly modulate activity in key populations of hypothalamic neurons that regulate food …

OLFR734 mediates glucose metabolism as a receptor of asprosin

E Li, H Shan, L Chen, A Long, Y Zhang, Y Liu, L Jia… - Cell metabolism, 2019 - cell.com
Asprosin is a fasting-induced hormone that promotes glucose production in the liver and
stimulates appetite in the hypothalamus by activating the cAMP signaling pathway via an …

Food odor perception promotes systemic lipid utilization

H Tsuneki, M Sugiyama, T Ito, K Sato, H Matsuda… - Nature …, 2022 - nature.com
Food cues during fasting elicit Pavlovian conditioning to adapt for anticipated food intake.
However, whether the olfactory system is involved in metabolic adaptations remains elusive …

Nature, smells, and human wellbeing

PR Bentley, JC Fisher, M Dallimer, RD Fish, GE Austen… - Ambio, 2023 - Springer
The link between nature and human wellbeing is well established. However, few studies go
beyond considering the visual and auditory underpinnings of this relationship, even though …

When the nose doesn't know: Canine olfactory function associated with health, management, and potential links to microbiota

EK Jenkins, MT DeChant, EB Perry - Frontiers in veterinary science, 2018 - frontiersin.org
The impact of health, management, and microbiota on olfactory function in canines has not
been examined in review. The most important characteristic of the detection canine is its …

Application of Caenorhabditis elegans in Lipid Metabolism Research

L An, X Fu, J Chen, J Ma - International journal of molecular sciences, 2023 - mdpi.com
Over the last decade, the development and prevalence of obesity have posed a serious
public health risk, which has prompted studies on the regulation of adiposity. With the ease …

A sex-specific thermogenic neurocircuit induced by predator smell recruiting cholecystokinin neurons in the dorsomedial hypothalamus

P Jovanovic, AH Pool, N Morones, Y Wang… - Nature …, 2023 - nature.com
Olfactory cues are vital for prey animals like rodents to perceive and evade predators. Stress-
induced hyperthermia, via brown adipose tissue (BAT) thermogenesis, boosts physical …

Smell & paste: Low-fidelity prototyping for olfactory experiences

J Brooks, P Lopes - Proceedings of the 2023 CHI Conference on Human …, 2023 - dl.acm.org
Low-fidelity prototyping is so foundational to Human-Computer Interaction, appearing in
most early design phases. So, how do experts prototype olfactory experiences? We …