Genipin-crosslinked albumin nanoparticles containing neratinib and silibinin: a dual-death therapy for triple negative breast cancer
R Ghadi, PK Pandey, A Gabhale, A Wadikar… - International Journal of …, 2023 - Elsevier
Triple negative breast cancer (TNBC) cells resist chemotherapy by hijacking apoptosis.
Alternative cell death forms like ferroptosis offer new treatment options. A combined therapy …
Alternative cell death forms like ferroptosis offer new treatment options. A combined therapy …
Synergistic anticancer therapy via ferroptosis using modified bovine serum albumin nanoparticles loaded with sorafenib and simvastatin
Ferroptosis is a non-apoptotic cell death pathway characterized by the accumulation of lipid-
peroxy radicals within the affected cells. Here, we investigate the synergistic capacity of …
peroxy radicals within the affected cells. Here, we investigate the synergistic capacity of …
Nanodrugs based on co-delivery strategies to combat cisplatin resistance
Q Wang, H Li, T Wu, B Yu, H Cong, Y Shen - Journal of Controlled Release, 2024 - Elsevier
Cisplatin (CDDP), as a broad-spectrum anticancer drug, is able to bind to DNA and inhibit
cell division. Despite the widespread use of cisplatin since its discovery, cisplatin resistance …
cell division. Despite the widespread use of cisplatin since its discovery, cisplatin resistance …
Unlocking apoptosis in triple negative breast cancer: Harnessing “glutamine trap” to amplify the efficacy of lapatinib-loaded mixed micelles
Certain aggressive cancers, such as triple-negative breast cancer (TNBC), heavily bank on
glutamine for their proliferation and survival. In this context, TNBC functions as a “glutamine …
glutamine for their proliferation and survival. In this context, TNBC functions as a “glutamine …
Exploring Sorafenib and Simvastatin Combination for Ferroptosis-Induced Cancer Treatment: Cytotoxicity Screening, InVivo Efficacy, and Safety Assessment
Ferroptosis, a pathway dependent on oxygen and iron catalysts, holds promise as a
therapeutic approach for cancer treatment due to its manageable regulation, direct control …
therapeutic approach for cancer treatment due to its manageable regulation, direct control …
Enhancing anti-cancer potential by delivering synergistic drug combinations via phenylboronic acid modified PLGA nanoparticles through ferroptosis-based therapy
In this study, we investigated the potential of the sorafenib (SOR) and simvastatin (SIM)
combination to induce ferroptosis-mediated cancer therapy. To enhance targeted drug …
combination to induce ferroptosis-mediated cancer therapy. To enhance targeted drug …
Advancing apoptosis induction in triple negative breast cancer: Empowering treatment with tyrosine-stapled mixed micelles of lapatinib
R Ghadi, A Wadikar, M Dharshini, V Yadav… - Journal of Molecular …, 2024 - Elsevier
The available treatment modalities for triple-negative breast cancer (TNBC) face several
challenges, including discouraging overall survival outcomes, unavoidable toxicities, and …
challenges, including discouraging overall survival outcomes, unavoidable toxicities, and …
Targeting FOXP3 tumor-intrinsic effects using adenoviral vectors in experimental breast cancer
AJ Nicola Candia, M Garcia Fallit, JA Peña Agudelo… - Viruses, 2023 - mdpi.com
The regulatory T cell master transcription factor, Forkhead box P3 (Foxp3), has been
detected in cancer cells; however, its role in breast tumor pathogenesis remains …
detected in cancer cells; however, its role in breast tumor pathogenesis remains …
Unveiling the potential of ursolic acid modified hyaluronate nanoparticles for combination drug therapy in triple negative breast cancer
Triple negative breast cancer (TNBC) represents the most aggressive and heterogenous
disease, and combination therapy holds promising potential. Here, an enzyme-responsive …
disease, and combination therapy holds promising potential. Here, an enzyme-responsive …
In-Silico Drug Toxicity and Interaction Prediction for Plant Complexes Based on Virtual Screening and Text Mining
Potential drug toxicities and drug interactions of redundant compounds of plant complexes
may cause unexpected clinical responses or even severe adverse events. On the other …
may cause unexpected clinical responses or even severe adverse events. On the other …