The biology of the HIV-1 latent reservoir and implications for cure strategies
Antiretroviral therapy (ART) inhibits HIV replication but is not curative. During ART, the
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …
The HIV reservoir in monocytes and macrophages
ME Wong, A Jaworowski, AC Hearps - Frontiers in immunology, 2019 - frontiersin.org
In people living with HIV (PLWH) who are failing or unable to access combination
antiretroviral therapy (cART), monocytes and macrophages are important drivers of …
antiretroviral therapy (cART), monocytes and macrophages are important drivers of …
HIV silencing and cell survival signatures in infected T cell reservoirs
Rare CD4 T cells that contain HIV under antiretroviral therapy represent an important barrier
to HIV cure,–, but the infeasibility of isolating and characterizing these cells in their natural …
to HIV cure,–, but the infeasibility of isolating and characterizing these cells in their natural …
Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy
JH Elliott, F Wightman, A Solomon, K Ghneim… - PLoS …, 2014 - journals.plos.org
Human immunodeficiency virus (HIV) persistence in latently infected resting memory CD4+
T-cells is the major barrier to HIV cure. Cellular histone deacetylases (HDACs) are important …
T-cells is the major barrier to HIV cure. Cellular histone deacetylases (HDACs) are important …
Recommendations for measuring HIV reservoir size in cure-directed clinical trials
M Abdel-Mohsen, D Richman, RF Siliciano… - Nature medicine, 2020 - nature.com
Therapeutic strategies are being clinically tested either to eradicate latent HIV reservoirs or
to achieve virologic control in the absence of antiretroviral therapy. Attaining this goal will …
to achieve virologic control in the absence of antiretroviral therapy. Attaining this goal will …
Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism
Progressive HIV infection is characterized by dysregulation of the intestinal immune barrier,
translocation of immunostimulatory microbial products, and chronic systemic inflammation …
translocation of immunostimulatory microbial products, and chronic systemic inflammation …
Antiretroviral-free HIV-1 remission and viral rebound after allogeneic stem cell transplantation: report of 2 cases
Background: It is unknown whether the reduction in HIV-1 reservoirs seen after allogeneic
hematopoietic stem cell transplantation (HSCT) with susceptible donor cells is sufficient to …
hematopoietic stem cell transplantation (HSCT) with susceptible donor cells is sufficient to …
Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies
HIV-1 reservoirs preclude virus eradication in patients receiving highly active antiretroviral
therapy (HAART). The best characterized reservoir is a small, difficult-to-quantify pool of …
therapy (HAART). The best characterized reservoir is a small, difficult-to-quantify pool of …
Tissue reservoirs of HIV
JK Wong, SA Yukl - Current Opinion in HIV and AIDS, 2016 - journals.lww.com
The retention of infected cells in a wide variety of tissues, often with distinct viral and cellular
characteristics, underscores the importance of studying tissue reservoirs in the development …
characteristics, underscores the importance of studying tissue reservoirs in the development …
HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study
TJ Henrich, H Hatano, O Bacon, LE Hogan… - PLoS …, 2017 - journals.plos.org
Background It is unknown if extremely early initiation of antiretroviral therapy (ART) may lead
to long-term ART-free HIV remission or cure. As a result, we studied 2 individuals recruited …
to long-term ART-free HIV remission or cure. As a result, we studied 2 individuals recruited …